methyl Hexadecanoate 3,4-Bis(dibenzyl phosphate)

Base Information

• Chemical Name: methyl Hexadecanoate 3,4-Bis(dibenzyl phosphate)
• CAS No.: 130277-70-2
• Molecular Formula: C₇₂H₈₈O₁₃P₂
• Molecular Weight: 1223.43
• Mol file: 130277-70-2.mol

Synonyms:

Chemical Property of methyl Hexadecanoate 3,4-Bis(dibenzyl phosphate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl Hexadecanoate 3,4-Bis(dibenzyl phosphate)

There total 30 articles about methyl Hexadecanoate 3,4-Bis(dibenzyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-myo-inositol (87-89-8) → methyl Hexadecanoate 4,5-Bis(dibenzyl phosphate) (130277-70-2,130324-64-0)

Guidance literature:

Multi-step reaction with 15 steps

1: 22.9 percent / TsOH / toluene; dimethylformamide / 2 h / 143 °C

2: 64.5 percent / KOH / 3.5 h / 100 - 125 °C

3: 80.4 percent / 1,2-dihydroxyethane, TsOH / CH₂Cl₂ / 0.78 h / 24 °C

4: NaH / dimethylformamide / 1 h / 25 - 60 °C

5: 1M aq. HCl / ethanol; toluene / 2.5 h / 60 °C

6: 1.) Bu₂SnO / 1.) toluene, 100 deg C, 45 min; 2.) DMF, 95 deg C, 1.5 h

7: 61.6 percent / NaH / dimethylformamide / 2 h / 25 - 40 °C

8: 82 percent / t-BuOK / dimethylsulfoxide / 19 h / 50 °C

9: 83 percent / 1M aq. HCl / ethanol; toluene / 8.5 h / 23 °C

10: 59 percent / pyridinium chlorochromate / CH₂Cl₂ / 19 h / 25 °C

11: 95 percent / BuLi / tetrahydrofuran / 0.37 h / 0 - 22 °C

12: 1.) BH₃*Me₂S; 2.) 5M NaOH, 30percent H₂O₂ / 1.) toluene, 25 - 68 deg C, 1.5 h; 2.) EtOH, 75 deg C, 5 min

13: 99 percent / pyridine / DMAP / CH₂Cl₂ / 1 h / 25 °C

14: 21 percent / DDQ, H₂O / CH₂Cl₂ / 1.5 h / 25 °C

15: 1.) 1H-tetrazole; 2.) m-chloroperbenzoic acid / 1.) CH₂Cl₂, 25 deg C; 2.) -40 deg C to 25 deg C

With pyridine; 1H-tetrazole; hydrogenchloride; potassium hydroxide; sodium hydroxide; n-butyllithium; dimethylsulfide borane complex; potassium tert-butylate; water; dihydrogen peroxide; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; ethylene glycol; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; dmap; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

DOI:10.1002/hlca.19900730428

Reference yield:

D-myo-inositol (87-89-8) → methyl Hexadecanoate 3,4-Bis(dibenzyl phosphate) (130277-70-2,130324-64-0)

Guidance literature:

Multi-step reaction with 15 steps

1: 22.9 percent / TsOH / toluene; dimethylformamide / 2 h / 143 °C

2: 64.5 percent / KOH / 3.5 h / 100 - 125 °C

3: 80.4 percent / 1,2-dihydroxyethane, TsOH / CH₂Cl₂ / 0.78 h / 24 °C

4: NaH / dimethylformamide / 1 h / 25 - 60 °C

5: 1M aq. HCl / ethanol; toluene / 2.5 h / 60 °C

6: 1.) Bu₂SnO / 1.) toluene, 100 deg C, 45 min; 2.) DMF, 95 deg C, 1.5 h

7: 61.6 percent / NaH / dimethylformamide / 2 h / 25 - 40 °C

8: 82 percent / t-BuOK / dimethylsulfoxide / 19 h / 50 °C

9: 83 percent / 1M aq. HCl / ethanol; toluene / 8.5 h / 23 °C

10: 59 percent / pyridinium chlorochromate / CH₂Cl₂ / 19 h / 25 °C

11: 95 percent / BuLi / tetrahydrofuran / 0.37 h / 0 - 22 °C

12: 1.) BH₃*Me₂S; 2.) 5M NaOH, 30percent H₂O₂ / 1.) toluene, 25 - 68 deg C, 1.5 h; 2.) EtOH, 75 deg C, 5 min

13: 99 percent / pyridine / DMAP / CH₂Cl₂ / 1 h / 25 °C

14: 45 percent / DDQ, H₂O / CH₂Cl₂ / 1.5 h / 25 °C

15: 1.) 1H-tetrazole; 2.) m-chloroperbenzoic acid / 1.) CH₂Cl₂, 25 deg C, 2.5 h; 2.) -40 deg C to RT, 1.5 h

With pyridine; 1H-tetrazole; hydrogenchloride; potassium hydroxide; sodium hydroxide; n-butyllithium; dimethylsulfide borane complex; potassium tert-butylate; water; dihydrogen peroxide; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; ethylene glycol; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; dmap; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

DOI:10.1002/hlca.19900730428

Reference yield:

1,2:4,5-dicyclohexylidene-myo-inositol (34361-60-9,55123-24-5,55123-26-7,62012-78-6,104873-71-4) → methyl Hexadecanoate 3,4-Bis(dibenzyl phosphate) (130277-70-2,130324-64-0)

Guidance literature:

Multi-step reaction with 14 steps

1: 64.5 percent / KOH / 3.5 h / 100 - 125 °C

2: 80.4 percent / 1,2-dihydroxyethane, TsOH / CH₂Cl₂ / 0.78 h / 24 °C

3: NaH / dimethylformamide / 1 h / 25 - 60 °C

4: 1M aq. HCl / ethanol; toluene / 2.5 h / 60 °C

5: 1.) Bu₂SnO / 1.) toluene, 100 deg C, 45 min; 2.) DMF, 95 deg C, 1.5 h

6: 61.6 percent / NaH / dimethylformamide / 2 h / 25 - 40 °C

7: 82 percent / t-BuOK / dimethylsulfoxide / 19 h / 50 °C

8: 83 percent / 1M aq. HCl / ethanol; toluene / 8.5 h / 23 °C

9: 59 percent / pyridinium chlorochromate / CH₂Cl₂ / 19 h / 25 °C

10: 95 percent / BuLi / tetrahydrofuran / 0.37 h / 0 - 22 °C

11: 1.) BH₃*Me₂S; 2.) 5M NaOH, 30percent H₂O₂ / 1.) toluene, 25 - 68 deg C, 1.5 h; 2.) EtOH, 75 deg C, 5 min

12: 99 percent / pyridine / DMAP / CH₂Cl₂ / 1 h / 25 °C

13: 45 percent / DDQ, H₂O / CH₂Cl₂ / 1.5 h / 25 °C

14: 1.) 1H-tetrazole; 2.) m-chloroperbenzoic acid / 1.) CH₂Cl₂, 25 deg C, 2.5 h; 2.) -40 deg C to RT, 1.5 h

With pyridine; 1H-tetrazole; hydrogenchloride; potassium hydroxide; sodium hydroxide; n-butyllithium; dimethylsulfide borane complex; potassium tert-butylate; water; dihydrogen peroxide; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; ethylene glycol; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; dmap; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

DOI:10.1002/hlca.19900730428

upstream raw materials:

Dibenzyl N,N-diisopropylphosphoramidite

methyl Hexadecanoate

D-myo-inositol

1,2:4,5-dicyclohexylidene-myo-inositol

Refernces