(R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine oxide

Base Information

• Chemical Name: (R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine oxide
• CAS No.: 541540-61-8
• Molecular Formula: C₂₅H₂₆FeNOP
• Molecular Weight: 443.308
• Mol file: 541540-61-8.mol

Synonyms:

Chemical Property of (R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine oxide

There total 3 articles about (R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

rac-2-(N,N-dimethylaminomethyl)-1-diphenylphosphanylferrocene + dihydrogen peroxide (7722-84-1) → [2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine oxide (854497-20-4,541540-61-8)

Guidance literature:

In methanol; (inert atm.); dropwise addn. of 30% H2O2 to a suspn. of iron complex in methanol at 0°C, react. for 30 min at room temp.; addn. of aq. Na2SO3, evapn. of methanol, extn. with CH2Cl2, washing withwater, drying (MgSO4), evapn., column chromy. (alumina, ether/methanol 99:1); elem. anal.;

Reference yield: 80.0%

Oxone (37222-66-5,70693-62-8,10058-23-8) + (R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine sulfide (74311-50-5,74311-52-7,74286-04-7) → (R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine oxide (541540-61-8,854497-20-4)

Guidance literature:

In tetrahydrofuran; methanol; (inert atm.); slow addn. of a soln. of oxone (pH 6-7) to a soln. of ironcomplex in THF/methanol 1:1 at 0°C, stirring at room temp. for 2 0 min; addn. of aq. Na2S2O3, extn. with CHCl3, drying (MgSO4), evapn., column chromy. (alumina, ether/methanol 99:1);

Reference yield:

Oxone (37222-66-5,70693-62-8,10058-23-8) + (R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine sulfide (74311-50-5,74311-52-7,74286-04-7) → (2-formylferrocenyl)diphenylphosphine oxide (1144039-26-8) + (R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine oxide (541540-61-8,854497-20-4)

Guidance literature:

In tetrahydrofuran; methanol; (inert atm.); slow addn. of a soln. of oxone (pH 6-7) to a soln. of ironcomplex in THF/methanol 1:1 at room temp., stirring for 20 min; addn. of aq. Na2S2O3, extn. with CHCl3, drying (MgSO4), evapn., column chromy. (alumina, ether/methanol 99:1);

upstream raw materials:

dihydrogen peroxide

Oxone

(R)-[2-(N,N-dimethylaminomethyl)ferrocenyl]diphenylphosphine sulfide

Downstream raw materials:

(R)-trimethyl[(2-diphenylphosphinyl)ferrocenylmethyl]ammonium iodide

trimethyl[(2-diphenylphosphinyl)ferrocenylmethyl]ammoniumiodide

Refernces