5-(BROMOMETHYL)-2-FLUOROPYRIDINE

Base Information

• Chemical Name: 5-(BROMOMETHYL)-2-FLUOROPYRIDINE
• CAS No.: 105827-74-5
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.015
• Hs Code.: 2933399090
• Mol file: 105827-74-5.mol

Synonyms:2-fluoro-5-bromomethylpyridine;2-fluoro-5-pyridylmethyl bromide;5-bromomethyl-2-fluoro-pyridine;

Chemical Property of 5-(BROMOMETHYL)-2-FLUOROPYRIDINE

Chemical Property:

• PSA: 12.89000
• LogP: 2.11560
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% purity ^*data from raw suppliers

5-(Bromomethyl)-2-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(Bromomethyl)-2-fluoropyridine is a useful reagent for preparation of N-Benzylisatinsulfonamides as potent caspase-3 inhibitors.

Technology Process of 5-(BROMOMETHYL)-2-FLUOROPYRIDINE

There total 3 articles about 5-(BROMOMETHYL)-2-FLUOROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-fluoro-5-methylpyridine (2369-19-9) → 5-(Bromomethyl)-2-fluoropyridine (105827-74-5)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In 1,2-dichloro-ethane; for 18h; Inert atmosphere; Reflux;

Reference yield:

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 5-(Bromomethyl)-2-fluoropyridine (105827-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / aq. HBF₄; NaNO₂ / 1 h / 0 - 50 °C

2: NBS; benzoyl peroxide / CCl₄ / 2 h / Heating

With N-Bromosuccinimide; tetrafluoroboric acid; sodium nitrite; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1016/j.jfluchem.2004.12.015

Reference yield:

→ 5-(Bromomethyl)-2-fluoropyridine (105827-74-5)

Guidance literature:

2-Fluor-5-methyl-pyridin, N-Bromsuccinimid, wenig Dibenzoylperoxid, sd. Tetrachlormethan;

DOI:10.1021/jm00285a008

upstream raw materials:

2-fluoro-5-methylpyridine

(5-methyl-pyridin-2-yl)amine

Downstream raw materials:

tert-butyl 4-((6-(6-methoxypyridin-3-ylamino)-5-(4-methyl-6-(methylthio)-1,3,5-triazin-2-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate

N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(piperazin-1-ylmethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-fluoropyridin-3-yl)methyl)piperazine-1-carboxylate

5-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-2-fluoropyridin-3-ylboronic acid

Refernces

• 1、 Duki?-Stefanovi?, Sladjana,Hang Lai, Thu,Toussaint, Magali,Clau?, Oliver,Jevti?, Ivana I.,Penji?evi?, Jelena Z.,Andri?, Deana,Ludwig, Friedrich-Alexander,Gündel, Daniel,Deuther-Conrad, Winnie,Kosti?-Raja?i?, Sladjana V.,Brust, Peter,Teodoro, Rodrigo. "In vitro and in vivo evaluation of fluorinated indanone derivatives as potential positron emission tomography agents for the imaging of monoamine oxidase B in the brain". supporting information. . Retrieved 2021/07/21.
• 2、 -. "PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS". Page/Page column 61. . Retrieved 2018/01/17.