Technology Process of 2-fluoro-1-(3-nitrophenyl)ethanol
There total 3 articles about 2-fluoro-1-(3-nitrophenyl)ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Rhodococcus ruber alcohol dehydrogenase A overexpressed in E. coli; NADH;
In
isopropyl alcohol;
at 30 ℃;
for 24h;
pH=7.5;
enantioselective reaction;
Enzymatic reaction;
DOI:10.1021/jo400962c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-Bromosuccinimide; toluene-4-sulfonic acid / acetonitrile / 24 h / 50 °C
2: potassium fluoride; zinc(II) fluoride / acetonitrile / 24 h / 100 °C
3: Rhodococcus ruber alcohol dehydrogenase A overexpressed in E. coli; NADH / isopropyl alcohol / 24 h / 30 °C / pH 7.5 / Enzymatic reaction
With
potassium fluoride; N-Bromosuccinimide; zinc(II) fluoride; Rhodococcus ruber alcohol dehydrogenase A overexpressed in E. coli; toluene-4-sulfonic acid; NADH;
In
isopropyl alcohol; acetonitrile;
DOI:10.1021/jo400962c
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium fluoride; zinc(II) fluoride / acetonitrile / 24 h / 100 °C
2: Rhodococcus ruber alcohol dehydrogenase A overexpressed in E. coli; NADH / isopropyl alcohol / 24 h / 30 °C / pH 7.5 / Enzymatic reaction
With
potassium fluoride; zinc(II) fluoride; Rhodococcus ruber alcohol dehydrogenase A overexpressed in E. coli; NADH;
In
isopropyl alcohol; acetonitrile;
DOI:10.1021/jo400962c