4-METHYLTHIO-ORTHO-CRESOL

Base Information

• Chemical Name: 4-METHYLTHIO-ORTHO-CRESOL
• CAS No.: 3795-76-4
• Molecular Formula: C8H10 O S
• Molecular Weight: 154.233
• Hs Code.: 2930909090
• Mol file: 3795-76-4.mol

Synonyms:o-Cresol,4-(methylthio)- (6CI,7CI,8CI); 2-Methyl-4-(methylthio)phenol; NSC 142469

Chemical Property of 4-METHYLTHIO-ORTHO-CRESOL

Chemical Property:

• Vapor Pressure: 0.00637mmHg at 25°C
• Boiling Point: 263.2°Cat760mmHg
• Flash Point: 128.5°C
• PSA: 45.53000
• Density: 1.15g/cm³
• LogP: 2.42250

Purity/Quality:

99% ^*data from raw suppliers

2-methyl-4-methylsulfanylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-METHYLTHIO-ORTHO-CRESOL

There total 6 articles about 4-METHYLTHIO-ORTHO-CRESOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

dimethyl(4-hydroxy-3-methylphenyl)sulfonium chloride (7379-36-4) → 4-methylthio-o-cresol (3795-76-4)

Guidance literature:

Heating;

DOI:10.1021/jm00359a021

Reference yield:

ortho-cresol (95-48-7,77504-84-8) → 4-methylthio-o-cresol (3795-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 26 percent / ClSO₂OH / diethyl ether / 12 h / Ambient temperature

2: 94 percent / Heating

With chlorosulfonic acid; In diethyl ether;

DOI:10.1021/jm00359a021

Reference yield:

Dimethyldisulphide (624-92-0) + ortho-cresol (95-48-7,77504-84-8) → 4-methylthio-o-cresol (3795-76-4) + methyl o-tolyl sulfide (14092-00-3) + 2-methyl-6-(methylsulfenyl)phenol (25674-55-9) + 2-methyl-4,6-bis(methylsulfenyl)phenol

Guidance literature:

With aluminium trichloride; In tetrachloromethane; for 1h; Heating;

DOI:10.1021/ma010961d

upstream raw materials:

Methanesulfenyl chloride

ortho-cresol

dimethyl(4-hydroxy-3-methylphenyl)sulfonium chloride

4-mercapto-2-methylphenol

Downstream raw materials:

4-methoxy-3-methylphenyl methyl sulphide

(2-Methyl-4-methylmercapto-phenoxy)-essigsaeure

(2-Methyl-4-methylmercapto-phenoxy)-acetylhydroxamsaeure

4-Methanesulfonyl-2-methyl-1-(4-nitro-phenoxy)-benzene

Refernces

• 1、 Kouge,Koizumi,Okai,Kato. "Peptide synthesis in aqueous solution. I. Application of p-dialkyl-sulfoniophenols as a water-soluble coupling reagent". . p. 2409 - 2418. Retrieved 2007/10/02.