N,N'-Dimethyloxamide

Base Information

• Chemical Name: N,N'-Dimethyloxamide
• CAS No.: 615-35-0
• Molecular Formula: C4H8N2O2
• Molecular Weight: 116.12
• European Community (EC) Number: 210-420-8
• NSC Number: 80645
• UNII: 573D5I9HQV
• DSSTox Substance ID: DTXSID80210468
• Nikkaji Number: J27.709F
• Wikidata: Q27261462
• Mol file: 615-35-0.mol

Synonyms:N,N'-dimethyloxamide

Chemical Property of N,N'-Dimethyloxamide

Chemical Property:

• Melting Point: 214-217 °C(lit.)
• PKA: 11.76±0.46(Predicted)
• PSA: 58.20000
• Density: 1.091 g/cm³
• LogP: -0.73980
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 116.058577502
• Heavy Atom Count: 8
• Complexity: 96.6

Purity/Quality:

99% ^*data from raw suppliers

N,N''-Dimethyloxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CNC(=O)C(=O)NC

Technology Process of N,N'-Dimethyloxamide

There total 23 articles about N,N'-Dimethyloxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

oxalyl dichloride (79-37-8) + methylamine (74-89-5) → N,N'-dimethyloxamide (615-35-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja106848y

Reference yield: 82.0%

methanol (67-56-1) + 1,3-dimethyl-2-methylamino-1,3,2-diazaphospholidine-2,4,5-trione (102146-42-9) → N,N'-dimethyloxamide (615-35-0) + dimethyl N-methylphosphoramidate (52420-88-9)

Guidance literature:

for 0.5h; Heating;

DOI:10.1039/P29860000017

Reference yield: 69.0%

5,5-diazido-1,3-dimethylbarbituric acid (930273-29-3) → N,N'-dimethyloxamide (615-35-0)

Guidance literature:

With sodium hydrogencarbonate; at 50 - 60 ℃; for 6h;

upstream raw materials:

sarcosine anhydride

N,N''-dimethyl-oxalamidine

N-cyanocarbonyl-N,N'-dimethyl-urea

1,3-dimethyluric acid

Downstream raw materials:

N,N'-dimethyl-N,N'-dinitroso-oxamide

oxalic acid

methylamine

4,5-dibromo-1-methyl-1H-imidazole

Refernces

• 1、 Saloutin, V. I.,Piterskikh, I. A.,Pashkevich, K. I.. "ESTERS OF FLUORINE-CONTAINING α-KETO ACIDS IN THE REACTION WITH AMINES". . p. 570 - 579. Retrieved 1986.
• 2、 Rastegar, Majid F.,Todd, Erin K.,Tang, Hongding,Wang, Zhi Yuan. "A new class of near-infrared electrochromic oxamide-based dinuclear ruthenium complexes". . p. 4519 - 4522. Retrieved 2007/10/03.