2-Phenyl-quinoline-8-carboxylic acid (5-dimethylamino-pentyl)-amide; hydrochloride

Base Information

• Chemical Name: 2-Phenyl-quinoline-8-carboxylic acid (5-dimethylamino-pentyl)-amide; hydrochloride
• CAS No.: 107026-89-1
• Molecular Formula: C₂₃H₂₇N₃O*ClH
• Molecular Weight: 397.948
• Mol file: 107026-89-1.mol

Synonyms:

Chemical Property of 2-Phenyl-quinoline-8-carboxylic acid (5-dimethylamino-pentyl)-amide; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Phenyl-quinoline-8-carboxylic acid (5-dimethylamino-pentyl)-amide; hydrochloride

There total 10 articles about 2-Phenyl-quinoline-8-carboxylic acid (5-dimethylamino-pentyl)-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → 2-Phenyl-quinoline-8-carboxylic acid (5-dimethylamino-pentyl)-amide; hydrochloride (107026-89-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 39 percent / methanesulfonic acid / benzene / 36 h / Heating

2: 35 percent / various solvent(s) / 255 °C

3: 98 percent / KOH / aq. ethanol / 2 h / Heating

4: 1.) KOH, Al-foil, 2) HCl, FeCl₃ / 1.) 50percent aq. EtOH, 2.) reflux, 30 min

5: 1.) 1,1'-carbonyldiimidazole, 3.) conc. HCl / 1.) DMF, 20 to 40 deg C, 20 min, 2.) 20 deg C, 15 min

With hydrogenchloride; potassium hydroxide; methanesulfonic acid; iron(III) chloride; 1,1'-carbonyldiimidazole; aluminium; In ethanol; benzene;

DOI:10.1021/jm00122a018

Reference yield:

benzaldehyde (100-52-7) → 2-Phenyl-quinoline-8-carboxylic acid (5-dimethylamino-pentyl)-amide; hydrochloride (107026-89-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 20 percent / ethanol / 3 h / Heating

2: 93 percent / Cu-powder / 280 - 290 °C

3: 34 percent / SeO₂ / a) 180 to 190 deg C, b) 280 to 290 deg C, 2 min

4: 1.) 1,1'-carbonyldiimidazole, 3.) conc. HCl / 1.) DMF, 20 to 40 deg C, 20 min, 2.) 20 deg C, 15 min

With hydrogenchloride; selenium(IV) oxide; copper; 1,1'-carbonyldiimidazole; In ethanol;

DOI:10.1021/jm00122a018

Reference yield:

2-carbomethoxyaniline (134-20-3) → 2-Phenyl-quinoline-8-carboxylic acid (5-dimethylamino-pentyl)-amide; hydrochloride (107026-89-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 39 percent / methanesulfonic acid / benzene / 36 h / Heating

2: 35 percent / various solvent(s) / 255 °C

3: 98 percent / KOH / aq. ethanol / 2 h / Heating

4: 1.) KOH, Al-foil, 2) HCl, FeCl₃ / 1.) 50percent aq. EtOH, 2.) reflux, 30 min

5: 1.) 1,1'-carbonyldiimidazole, 3.) conc. HCl / 1.) DMF, 20 to 40 deg C, 20 min, 2.) 20 deg C, 15 min

With hydrogenchloride; potassium hydroxide; methanesulfonic acid; iron(III) chloride; 1,1'-carbonyldiimidazole; aluminium; In ethanol; benzene;

DOI:10.1021/jm00122a018

upstream raw materials:

2-phenylquinoline-8-carboxylic acid

N,N-dimethyl-1,5-pentanediamine

8-methyl-2-phenylquinoline

2-phenyl-8-methylquinoline-4-carboxylic acid

Refernces