4-METHYLPIPERIDIN-4-OL

Base Information

• Chemical Name: 4-METHYLPIPERIDIN-4-OL
• CAS No.: 3970-68-1
• Molecular Formula: C6H13NO
• Molecular Weight: 115.175
• Hs Code.: 2933399090
• Mol file: 3970-68-1.mol

Synonyms:4-Hydroxy-4-methylpiperidine;4-Methyl-4-hydroxypiperidine;4-Methyl-4-piperidinol;4-Pipecolin-4-ol;

Chemical Property of 4-METHYLPIPERIDIN-4-OL

Chemical Property:

• Vapor Pressure: 0.209mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 184.425 °C at 760 mmHg
• PKA: 15.01±0.20(Predicted)
• Flash Point: 79.471 °C
• PSA: 32.26000
• Density: 0.977 g/cm³
• LogP: 0.44960
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99.0% ^*data from raw suppliers

4-Methylpiperidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYLPIPERIDIN-4-OL

There total 9 articles about 4-METHYLPIPERIDIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-benzyl-4-methyl-piperidin-4-ol (3970-66-9) → 4-methylpiperidin-4-ol (3970-68-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 22 ℃; for 19.5h; under 3102.97 Torr;

Reference yield: 99.0%

tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate (406235-30-1) → 4-methylpiperidin-4-ol (3970-68-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 72.0%

benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate (169750-57-6) → 4-methylpiperidin-4-ol (3970-68-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; under 2585.81 Torr; Inert atmosphere;

upstream raw materials:

benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate

1-benzyl-4-methyl-piperidin-4-ol

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate

Downstream raw materials:

1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4R)-4-[3-(4-methyl-4-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea

1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(4-hydroxy-4-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

C₁₉H₁₈F₄N₂O₄S

C₁₉H₁₉ClF₂N₂O₄S

Refernces

• 1、 Luo, Zonghua,Liu, Hui,Klein, Robyn S.,Tu, Zhude. "Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor". . p. 3619 - 3631. Retrieved 2019/07/05.
• 2、 -. "FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS". . . Retrieved 2016/07/05.