(D,L)-cis 4-guanidinocyclohexylglycine methyl ester dihydrochloride

Base Information

• Chemical Name: (D,L)-cis 4-guanidinocyclohexylglycine methyl ester dihydrochloride
• CAS No.: 126455-18-3
• Molecular Formula: C₁₀H₂₀N₄O₂*2ClH
• Molecular Weight: 301.216
• Mol file: 126455-18-3.mol

Synonyms:

Chemical Property of (D,L)-cis 4-guanidinocyclohexylglycine methyl ester dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (D,L)-cis 4-guanidinocyclohexylglycine methyl ester dihydrochloride

There total 35 articles about (D,L)-cis 4-guanidinocyclohexylglycine methyl ester dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

methanol (67-56-1) + trans-(D)-4-guanidinocyclohexylglycine (126455-20-7,126455-21-8,130696-78-5,130696-79-6) → trans-(D)-4-guanidinocyclohexylglycine methyl ester dihydrochloride (126455-18-3,126455-19-4,130696-86-5,130696-87-6)

Guidance literature:

With thionyl chloride; Ambient temperature;

Reference yield: 83.1%

methanol (67-56-1) + cis-(D)-4-guanidinocyclohexylglycine (126455-20-7,126455-21-8,130696-78-5,130696-79-6) → cis-(D)-4-guanidinocyclohexylglycine methyl ester dihydrochloride (126455-18-3,126455-19-4,130696-86-5,130696-87-6)

Guidance literature:

With thionyl chloride; Ambient temperature;

Reference yield: 80.0%

methanol (67-56-1) + (D,L)-cis 4-guanidinocyclohexylglycine (126455-20-7) → (D,L)-cis 4-guanidinocyclohexylglycine methyl ester dihydrochloride (126455-18-3,126455-19-4,130696-86-5,130696-87-6)

Guidance literature:

With thionyl chloride; 1.) 0 deg C, 2.) room temperature;

upstream raw materials:

methanol

trans-(D)-4-guanidinocyclohexylglycine

(R)-phenylglycine

2-(R)-acetamido-2-(4'-aminocyclohexyl)-acetic acid

Refernces

• 1、 Banfi, Aldo,Benedini, Francesca,Sala, Alberto,Russo, Giovanni. "Synthesis of Optically Pure Analogue of D-Arginine Methyl Ester with Antiarrhythmic Activity". . p. 3585 - 3597. Retrieved 2007/10/02.