benzoylamino-(3-nitro-benzyl)-malonic acid diethyl ester

Base Information

• Chemical Name: benzoylamino-(3-nitro-benzyl)-malonic acid diethyl ester
• CAS No.: 112441-37-9
• Molecular Formula: C₂₁H₂₂N₂O₇
• Molecular Weight: 414.415
• Mol file: 112441-37-9.mol

Synonyms:

Chemical Property of benzoylamino-(3-nitro-benzyl)-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoylamino-(3-nitro-benzyl)-malonic acid diethyl ester

There total 1 articles about benzoylamino-(3-nitro-benzyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl benzamidomalonate (96-86-6) → benzoylamino-(3-nitro-benzyl)-malonic acid diethyl ester (112441-37-9)

Guidance literature:

With ethanol; sodium ethanolate; anschliessend Erwaermen mit 3-Nitro-benzylbromid;

DOI:10.1021/ja01521a047

Reference yield:

benzoylamino-(3-nitro-benzyl)-malonic acid diethyl ester (112441-37-9) → (3-amino-benzyl)-benzoylamino-malonic acid diethyl ester (111161-91-2)

Guidance literature:

With methanol; palladium on activated charcoal; ethyl acetate; Hydrogenation;

DOI:10.1021/ja01521a047

Reference yield:

benzoylamino-(3-nitro-benzyl)-malonic acid diethyl ester (112441-37-9) → benzoylamino-{3-[bis-(2-hydroxy-ethyl)-amino]-benzyl}-malonic acid diethyl ester (103758-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/charcoal; ethyl acetate; methanol / Hydrogenation

2: aqueous acetic acid

With methanol; palladium on activated charcoal; acetic acid; ethyl acetate;

DOI:10.1021/ja01521a047

upstream raw materials:

diethyl benzamidomalonate

Downstream raw materials:

(3-amino-benzyl)-benzoylamino-malonic acid diethyl ester

benzoylamino-{3-[bis-(2-hydroxy-ethyl)-amino]-benzyl}-malonic acid diethyl ester