3-Ethyl-2-propylquinoline

Base Information

• Chemical Name: 3-Ethyl-2-propylquinoline
• CAS No.: 3290-24-2
• Molecular Formula: C14H17N
• Molecular Weight: 199.296
• Hs Code.: 2933499090
• European Community (EC) Number: 221-948-3
• DSSTox Substance ID: DTXSID1062960
• Nikkaji Number: J262.392G
• Wikidata: Q81990383
• Mol file: 3290-24-2.mol

Synonyms:3-Ethyl-2-propylquinoline;3290-24-2;EINECS 221-948-3;2-Propyl-3-ethylquinoline;Quinoline, 3-ethyl-2-propyl-;Quinoline,3-ethyl-2-propyl-;3-ethyl-2-propyl-quinoline;Quinoline, 3-ethyl-2-propyl;DTXSID1062960;AKOS015949571;FT-0685615;J-512421

Chemical Property of 3-Ethyl-2-propylquinoline

Chemical Property:

• Vapor Pressure: 0.00326mmHg at 25°C
• Refractive Index: 1.576
• Boiling Point: 292.2 °C at 760 mmHg
• Flash Point: 117.8 °C
• PSA: 12.89000
• Density: 1.001 g/cm³
• LogP: 3.74970
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 199.136099547
• Heavy Atom Count: 15
• Complexity: 190

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=NC2=CC=CC=C2C=C1CC

Technology Process of 3-Ethyl-2-propylquinoline

There total 53 articles about 3-Ethyl-2-propylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

butyraldehyde (123-72-8) + nitrobenzene (98-95-3,26969-40-4) → 3-ethyl-2-propylquinoline (3290-24-2)

Guidance literature:

With phosphomolybdic acid; hydrazine hydrate; In water; at 40 - 50 ℃; for 2.5h; regioselective reaction;

DOI:10.1002/jccs.200800177

Reference yield: 95.0%

butyraldehyde (123-72-8) + aniline (62-53-3) → N-(n-butyl)aniline (1126-78-9) + 3-ethyl-2-propylquinoline (3290-24-2)

Guidance literature:

LnCl₃*6H₂O; In N,N-dimethyl-formamide; for 0.166667h;

DOI:10.1134/S1070428006100307

Reference yield: 93.0%

butyraldehyde (123-72-8) + aniline (62-53-3) → 3-ethyl-2-propylquinoline (3290-24-2)

Guidance literature:

praseodymium(III) chloride; N,N-dimethyl-formamide; triphenylphosphine; at 100 ℃; for 6h;

DOI:10.1007/BF01557745

upstream raw materials:

1,3-diethyl-2-propyl-1,2-dihydro-quinoline

4-anilino-3-[(phenylimino)methyl]heptane

butyraldehyde

aniline

Refernces

• 1、 Watanabe, Yoshihisa,Suzuki, Naoki,Shim, Sang Chul,Yamamoto, Michihiro,Mitsudo, Take-aki,Takegami, Yoshinobu. "THE TRANSITION METAL-CATALYZED N-ALKYLATION AND N-HETEROCYCLIZATION. A REDUCTIVE TRANSFORMATION OF NITROBENZENE INTO N,N-DIALKYLANILINE AND 2,3-SUBSTITUTED QUINOLINE USING ALDEHYDE AND CARBON MONOXIDE". . p. 429 - 430. Retrieved 1980.
• 2、 Cho, Chan Sik,Lee, Na Young,Kim, Tae-Jeong,Shim, Sang Chul. "Ruthenium-catalyzed formal alkyl group transfer: Synthesis of quinolines from nitroarenes and alkylammonium halides". . p. 423 - 429. Retrieved 2004.
• 3、 -. "Method for preparing quinoline compound through oxidation and reduction integration (by machine translation)". Paragraph 0047-0048. . Retrieved 2020/02/17.
• 4、 Ali, Saghir,Gattu, Radhakrishna,Singh, Varun,Mondal, Santa,Khan, Abu T.,Dubey, Gurudutt,Bharatam. "Reaction behaviour of arylamines with nitroalkenes in the presence of bismuth(iii) triflate: An easy access to 2,3-dialkylquinolines". . p. 1785 - 1793. Retrieved 2020/03/17.