Benzimidazo[1,2-c]quinazoline, 6-(4-chlorophenyl)-

Base Information

• Chemical Name: Benzimidazo[1,2-c]quinazoline, 6-(4-chlorophenyl)-
• CAS No.: 105997-06-6
• Molecular Formula: C20H12ClN3
• Molecular Weight: 329.788
• Mol file: 105997-06-6.mol

Synonyms:

Chemical Property of Benzimidazo[1,2-c]quinazoline, 6-(4-chlorophenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzimidazo[1,2-c]quinazoline, 6-(4-chlorophenyl)-

There total 11 articles about Benzimidazo[1,2-c]quinazoline, 6-(4-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(aminophenyl)benzimidazole (5805-39-0) + 4-chloro-benzoyl chloride (122-01-0) → 6-(4-chlorophenyl)benzo[4,5]imidazo[1,2-c]quinazoline (105997-06-6)

Guidance literature:

In acetic anhydride; acetic acid; Heating;

DOI:10.1007/BF00758335

Reference yield: 79.0%

2-(2-bromophenyl)-benzimidazole (13275-42-8) + 4-chlorobenzaldehyde (104-88-1) → 6-(4-chlorophenyl)benzo[4,5]imidazo[1,2-c]quinazoline (105997-06-6)

Guidance literature:

With sodium azide; copper; caesium carbonate; L-proline; In dimethyl sulfoxide; at 80 ℃; for 12h;

DOI:10.1039/c5ra15525h

Reference yield: 78.0%

2-(2-iodophenyl)-1H-benzo[d]imidazole (24192-81-2) + 2-(4-Chlorophenyl)glycine (6212-33-5,7292-70-8) → 6-(4-chlorophenyl)benzo[4,5]imidazo[1,2-c]quinazoline (105997-06-6)

Guidance literature:

2-(2-iodophenyl)-1H-benzo[d]imidazole; 2-(4-Chlorophenyl)glycine; With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 36h; Green chemistry;

With oxygen; In N,N-dimethyl-formamide; at 90 ℃; for 36h; under 760.051 Torr; Green chemistry;

DOI:10.1039/c3ra41644e

upstream raw materials:

2-(aminophenyl)benzimidazole

4-chloro-benzoyl chloride

2-(4-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one

1,2-diamino-benzene

Downstream raw materials:

C₂₆H₂₄BN₃O₂

Refernces

• 1、 Rai, Byanju,Kumar, Promod,Kumar, Atul. "Copper-mediated aerobic oxidative synthesis of benzimidazo fused quinazolines via a multicomponent approach". . p. 85915 - 85918. Retrieved 2015/11/03.
• 2、 Pessoa-Mahana, Hernan,Pessoa-Mahana, C. David,Salazar, Ricardo,Valderrama, Jaime A.,Saez, Edmundo,Araya-Maturana, Ramiro. "Solvent-Free Synthesis of 6-Arylbenzimidazo[1,2-c]quinazolines under Microwave Irradiation". . p. 436 - 440. Retrieved 2007/10/03.