2,4-DIETHOXYPYRIMIDINE

Base Information

• Chemical Name: 2,4-DIETHOXYPYRIMIDINE
• CAS No.: 20461-60-3
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168.195
• Hs Code.: 29335990
• Mol file: 20461-60-3.mol

Synonyms:2,4-Diethoxypyrimidine;NSC 13689;

Chemical Property of 2,4-DIETHOXYPYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.0114mmHg at 25°C
• Refractive Index: 1.486
• Boiling Point: 270.3 °C at 760 mmHg
• Flash Point: 99.1 °C
• PSA: 44.24000
• Density: 1.071 g/cm³
• LogP: 1.27400
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,4-Diethoxypyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIETHOXYPYRIMIDINE

There total 8 articles about 2,4-DIETHOXYPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,6-Dichloropyrimidine (3934-20-1) + ethanol (64-17-5) → 2,4-diethoxypyrimidine (20461-60-3)

Guidance literature:

With caesium carbonate; In neat (no solvent); at 100 ℃; for 16h; Sealed tube;

DOI:10.1002/asia.202101370

Reference yield:

diethyl sulfate (64-67-5) + uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) → 3-ethyl-2,4(1H)-pyrimidinedione (5148-09-4) + 2,4-diethoxypyrimidine (20461-60-3) + 1,3-diethyluracil (22390-04-1) + 4-ethoxy-1-ethyl-2(1H)-pyrimidinone (25902-95-8)

Guidance literature:

uracil; With potassium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h;

diethyl sulfate; In N,N-dimethyl-formamide; at 60 ℃; for 72h; Further byproducts given;

DOI:10.1016/j.tet.2006.04.098

Reference yield:

4-chloro-2,6-diethoxypyrimidine (93232-55-4) → 2,4-diethoxypyrimidine (20461-60-3)

Guidance literature:

With hydrogenchloride; zinc; at 50 - 60 ℃;

upstream raw materials:

2,6-Dichloropyrimidine

sodium ethanolate

4-chloro-2,6-diethoxypyrimidine

ethanol

Downstream raw materials:

CYTIDINE

uracil

2-<(4-ethoxy-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl dibenzoate

1-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>-4-ethoxy-2-pyrimidinone

Refernces

• 1、 Gambacorta, Augusto,Tofani, Daniela,Loreto, Maria Antonietta,Gasperi, Tecla,Bernini, Roberta. "HSAB-driven chemoselective N1-alkylation of pyrimidine bases and their 4-methoxy- or 4-acetylamino-derivatives". . p. 6848 - 6854. Retrieved 2007/10/03.
• 2、 Al-Awadi, Nouria,Taylor, Roger. "The Mechanism of Thermal Eliminations. Part 18. Relative Rates of Pyrolysis of 2-Ethoxypyrazine, 3-Ethoxypyridazine, 2-and 4-Ethoxypyrimidine, 3-Chloro-6-ethoxypyridazine, and 2-Chloro-4-ethoxypyrimidine : the Effect of the Aza 'Substituent' and ?-Bond Order on the Elimination Rate". . p. 1255 - 1258. Retrieved 2007/10/02.