6-ETHYL[1,3]BENZIMIDAZO[1,2-C]QUINAZOLINE

Base Information

• Chemical Name: 6-ETHYL[1,3]BENZIMIDAZO[1,2-C]QUINAZOLINE
• CAS No.: 238420-46-7
• Molecular Formula: C₁₆H₁₃N₃
• Molecular Weight: 247.299
• Mol file: 238420-46-7.mol

Synonyms:

Chemical Property of 6-ETHYL[1,3]BENZIMIDAZO[1,2-C]QUINAZOLINE

Chemical Property:

Purity/Quality:

6-ETHYL[1,3]BENZIMIDAZO[1,2-C]QUINAZOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-ETHYL[1,3]BENZIMIDAZO[1,2-C]QUINAZOLINE

There total 8 articles about 6-ETHYL[1,3]BENZIMIDAZO[1,2-C]QUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(aminophenyl)benzimidazole (5805-39-0) + Triethyl orthopropionate (115-80-0) → 6-ethylbenzimidazo<1,2-c>quinazoline (238420-46-7)

Guidance literature:

In N,N-dimethyl acetamide; for 0.1h; Irradiation;

DOI:10.1080/00397919908086422

Reference yield:

1,2-diamino-benzene (95-54-5) → 6-ethylbenzimidazo<1,2-c>quinazoline (238420-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / 70 °C

2: N,N-dimethyl-formamide / 12 h / 100 °C

In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bioorg.2020.103774

Reference yield:

isatoic anhydride (118-48-9) → 6-ethylbenzimidazo<1,2-c>quinazoline (238420-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / 70 °C

2: N,N-dimethyl-formamide / 12 h / 100 °C

In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bioorg.2020.103774

upstream raw materials:

2-(aminophenyl)benzimidazole

Propionamid

Triethyl orthopropionate

N-<2-aminobenzoil>-o-fenilendiamina

Refernces

• 1、 Chakraborti, Asit K.,Dhameliya, Tejas M.,Jadhavar, Pradeep S.,Krishna, Vagolu Siva,Patel, Kshitij I.,Saha, Nirjhar,Sriram, Dharmarajan,Vaja, Maulikkumar D.. "Benzimidazoquinazolines as new potent anti-TB chemotypes: Design, synthesis, and biological evaluation". . . Retrieved 2020/03/31.