1-octadecyl-2,3-dibenzylglycerol

Base Information

• Chemical Name: 1-octadecyl-2,3-dibenzylglycerol
• CAS No.: 197306-92-6
• Molecular Formula: C₃₅H₅₆O₃
• Molecular Weight: 524.828
• Mol file: 197306-92-6.mol

Synonyms:

Chemical Property of 1-octadecyl-2,3-dibenzylglycerol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-octadecyl-2,3-dibenzylglycerol

There total 1 articles about 1-octadecyl-2,3-dibenzylglycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-octadecyl methanesulfonate (31081-59-1) + (2S)-2,3-bis(benzyloxy)propanol (20196-71-8) → 1-octadecyl-2,3-dibenzylglycerol (197306-92-6)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, 50-55 deg C, 30 min, 2.) THF, reflux, 8 h;

DOI:10.1016/S0957-4166(97)00341-8

Reference yield: 82.0%

1-octadecyl-2,3-dibenzylglycerol (197306-92-6) → (R)-octadecylglycerol (10567-22-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; chloroform; for 12h; Ambient temperature;

DOI:10.1016/S0957-4166(97)00341-8

Reference yield:

1-octadecyl-2,3-dibenzylglycerol (197306-92-6) → 1-octadecyl-2-palmitoyl-D-glycerol (6068-25-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / H₂ / 10percent Pd/C / methanol; CHCl₃ / 12 h / Ambient temperature

2: 93.5 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂; dimethylformamide / 24 h / Ambient temperature

3: 60 percent / 4-(N,N-dimethylamino)pyridine, DCC / CH₂Cl₂ / 96 h / Ambient temperature

4: 75 percent / pyridinium p-toluenesulfonate, MeOH / CH₂Cl₂ / 0 - 5 °C

With methanol; dmap; hydrogen; pyridinium p-toluenesulfonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(97)00341-8

upstream raw materials:

1-octadecyl methanesulfonate

(2S)-2,3-bis(benzyloxy)propanol

Downstream raw materials:

(R)-octadecylglycerol

1-octadecyl-2-palmitoyl-D-glycerol

Refernces