4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

Base Information

• Chemical Name: 4-oxo-1,4-dihydro-3-pyridinecarboxylic acid
• CAS No.: 72676-96-1
• Molecular Formula: C6H5NO3
• Molecular Weight: 139.1088
• Hs Code.: 2933399090
• Mol file: 72676-96-1.mol

Synonyms:Nicotinicacid, 1,4-dihydro-4-oxo- (6CI);1,4-Dihydro-4-oxo-3-pyridinecarboxylic acid;

Chemical Property of 4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

Chemical Property:

• Boiling Point: 312.7 °C at 760 mmHg
• Flash Point: 142.9 °C
• PSA: 70.16000
• Density: 1.451 g/cm³
• LogP: 0.07310

Purity/Quality:

99% ^*data from raw suppliers

4-Oxo-1,4-dihydropyridine-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

There total 4 articles about 4-oxo-1,4-dihydro-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-chloronicotinic acid → 1,4-dihydro-4-oxopyridine-3-carboxylic acid (72676-96-1)

Guidance literature:

With water; Reflux;

DOI:10.1055/s-0037-1611435

Reference yield: 75.0%

4-chloronicotinic acid (10177-29-4) → 1,4-dihydro-4-oxopyridine-3-carboxylic acid (72676-96-1)

Guidance literature:

With water; for 2h; Reflux;

DOI:10.1021/acs.jmedchem.5b01357

Reference yield:

4-Chloropyridine (626-61-9) → 1,4-dihydro-4-oxopyridine-3-carboxylic acid (72676-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: water / 2 h / Reflux

With water; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/acs.jmedchem.5b01357

upstream raw materials:

4-Chloropyridine

4-chloronicotinic acid

Downstream raw materials:

1-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

N-<4-(4-diphenylmethyl-1-piperazinyl)butyl>-1,4-dihydro-4-oxopyridine-3-carboxamide

Refernces

• 1、 Cheung, Peter K.,Horhant, David,Bandy, Laura E.,Zamiri, Maryam,Rabea, Safwat M.,Karagiosov, Stoyan K.,Matloobi, Mitra,McArthur, Steven,Harrigan, P. Richard,Chabot, Benoit,Grierson, David S.. "A Parallel Synthesis Approach to the Identification of Novel Diheteroarylamide-Based Compounds Blocking HIV Replication: Potential Inhibitors of HIV-1 Pre-mRNA Alternative Splicing". . p. 1869 - 1879. Retrieved 2016/03/22.