cis-2,2-Dimethyl-3-phenyl-4-(4''-methoxycyclohexyl)-7-methoxychroman

Base Information

• Chemical Name: cis-2,2-Dimethyl-3-phenyl-4-(4''-methoxycyclohexyl)-7-methoxychroman
• CAS No.: 120186-53-0
• Molecular Formula: C₂₅H₃₂O₃
• Molecular Weight: 380.527
• Mol file: 120186-53-0.mol

Synonyms:

Chemical Property of cis-2,2-Dimethyl-3-phenyl-4-(4''-methoxycyclohexyl)-7-methoxychroman

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2,2-Dimethyl-3-phenyl-4-(4''-methoxycyclohexyl)-7-methoxychroman

There total 7 articles about cis-2,2-Dimethyl-3-phenyl-4-(4''-methoxycyclohexyl)-7-methoxychroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

methanol (67-56-1) + 4-(4-hydroxyphenyl)-7-methoxy-2,2-dimethyl-3-phenyl-2H-benzopyran (51423-23-5) → cis-2,2-Dimethyl-3-phenyl-4-(4''-hydroxycyclohexyl)-7-methoxychroman (120186-52-9) + cis-2,2-Dimethyl-3-phenyl-4-(4''-oxocyclohexyl)-7-methoxychroman (120186-51-8) + cis-2,2-Dimethyl-3-phenyl-4-(4''-methoxycyclohexyl)-7-methoxychroman (120186-53-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 70 - 80 ℃; for 4h; under 51714.8 Torr;

Reference yield:

4-(4-hydroxyphenyl)-7-methoxy-2,2-dimethyl-3-phenyl-2H-benzopyran (51423-23-5) → 7-Methoxy-4-(4-methoxy-cyclohexyl)-2,2-dimethyl-3-phenyl-chroman (120186-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1. H₂; 2. Jones' reagent / 1. Pd/C / 1. THF, 1000psi, 60-70 deg C; 2. acetone, 10min

2: acid / tetrahydrofuran

3: BuLi / dimethylsulfoxide

With n-butyllithium; jones' reagent; hydrogen; palladium on activated charcoal; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

4-(4-hydroxyphenyl)-7-methoxy-2,2-dimethyl-3-phenyl-2H-benzopyran (51423-23-5) → cis-2,2-Dimethyl-3-phenyl-4-(4''-methoxycyclohexyl)-7-methoxychroman (120186-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1. H₂; 2. Jones' reagent / 1. Pd/C / 1. THF, 1000psi, 60-70 deg C; 2. acetone, 10min

2: acid / tetrahydrofuran

With jones' reagent; hydrogen; palladium on activated charcoal; In tetrahydrofuran;

upstream raw materials:

4-(4-hydroxyphenyl)-7-methoxy-2,2-dimethyl-3-phenyl-2H-benzopyran

cis-2,2-Dimethyl-3-phenyl-4-(4''-oxocyclohexyl)-7-methoxychroman

methanol

Refernces