bis(5'-tert-butyl-3',4'-bis(methoxymethyloxy)phenyl)-3,5-di-tert-butyl-4-oxophenylmethane

Base Information

• Chemical Name: bis(5'-tert-butyl-3',4'-bis(methoxymethyloxy)phenyl)-3,5-di-tert-butyl-4-oxophenylmethane
• CAS No.: 219948-13-7
• Molecular Formula: C₄₃H₆₂O₉
• Molecular Weight: 722.96
• Mol file: 219948-13-7.mol

Synonyms:

Chemical Property of bis(5'-tert-butyl-3',4'-bis(methoxymethyloxy)phenyl)-3,5-di-tert-butyl-4-oxophenylmethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis(5'-tert-butyl-3',4'-bis(methoxymethyloxy)phenyl)-3,5-di-tert-butyl-4-oxophenylmethane

There total 4 articles about bis(5'-tert-butyl-3',4'-bis(methoxymethyloxy)phenyl)-3,5-di-tert-butyl-4-oxophenylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-Bromo-2,6-di-tert-butylphenoxy)trimethylsilane (27329-74-4) → bis(5'-tert-butyl-3',4'-bis(methoxymethyloxy)phenyl)-3,5-di-tert-butyl-4-oxophenylmethane (219948-13-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) t-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C to rt

2: aq. HCl / diethyl ether / Heating

3: 1.) LDA / 1.) THF, -78 deg C, 10 min, 2.) THF, reflux, overnight

With hydrogenchloride; tert.-butyl lithium; lithium diisopropyl amide; In diethyl ether;

DOI:10.1021/jo981597s

Reference yield:

3,5-di-tert-butyl-4-trimethylsilanyloxy-benzoic acid → bis(5'-tert-butyl-3',4'-bis(methoxymethyloxy)phenyl)-3,5-di-tert-butyl-4-oxophenylmethane (219948-13-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. HCl / diethyl ether / Heating

2: 1.) LDA / 1.) THF, -78 deg C, 10 min, 2.) THF, reflux, overnight

With hydrogenchloride; lithium diisopropyl amide; In diethyl ether;

DOI:10.1021/jo981597s

Reference yield:

methyl 3,5-di-tert-butyl-4-hydroxybenzoate (2511-22-0) → bis(5'-tert-butyl-3',4'-bis(methoxymethyloxy)phenyl)-3,5-di-tert-butyl-4-oxophenylmethane (219948-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 10 min, 2.) THF, reflux, overnight

With lithium diisopropyl amide;

DOI:10.1021/jo981597s

upstream raw materials:

methyl 3,5-di-tert-butyl-4-(trimethylsilyloxy)benzoate

(4-Bromo-2,6-di-tert-butylphenoxy)trimethylsilane

methyl 3,5-di-tert-butyl-4-hydroxybenzoate

Downstream raw materials:

4-[bis-(3-tert-butyl-4,5-dihydroxy-phenyl)-methylene]-2,6-di-tert-butyl-cyclohexa-2,5-dienone

Refernces