(7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1

Base Information

• Chemical Name: (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1
• CAS No.: 1369916-93-7
• Molecular Formula: C₂₄H₃₂O₆
• Molecular Weight: 416.514
• Mol file: 1369916-93-7.mol

Synonyms:

Chemical Property of (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1

There total 6 articles about (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester (1369917-11-2) → (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 (1369916-93-7)

Guidance literature:

In ethanol; at 20 ℃; for 1.5h; pH=7.4; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1248/cpb.59.1494

Reference yield:

7-hydroxy-11,15-bis-O-(tert-butyldimethylsilyl)-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester (1369917-07-6) → (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 (1369916-93-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; methanesulfonyl chloride / dichloromethane / 3 h / 0 °C

2: pyridine; pyridine hydrofluoride / acetonitrile / 1.5 h / Cooling with ice

3: ethanol / 1.5 h / 20 °C / pH 7.4 / aq. phosphate buffer; Enzymatic reaction

With pyridine; dmap; pyridine hydrofluoride; methanesulfonyl chloride; In ethanol; dichloromethane; acetonitrile;

DOI:10.1248/cpb.59.1494

Reference yield:

(7E)-7,8-didehydro-11,15-bis-O-(tert-butyldimethylsilyl)-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester (1369917-08-7) → (7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 (1369916-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; pyridine hydrofluoride / acetonitrile / 1.5 h / Cooling with ice

2: ethanol / 1.5 h / 20 °C / pH 7.4 / aq. phosphate buffer; Enzymatic reaction

With pyridine; pyridine hydrofluoride; In ethanol; acetonitrile;

DOI:10.1248/cpb.59.1494

upstream raw materials:

7-hydroxy-11,15-bis-O-(tert-butyldimethylsilyl)-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

(7E)-7,8-didehydro-11,15-bis-O-(tert-butyldimethylsilyl)-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

(7E)-7,8-didehydro-16-(3-methoxymethyl)phenyl-ω-tetranor-PGE1 methyl ester

methyl 7-oxoheptanoate

Refernces