Cyclopropanecarboxylic acid anhydride

Base Information

• Chemical Name: Cyclopropanecarboxylic acid anhydride
• CAS No.: 33993-24-7
• Molecular Formula: C8H10 O3
• Molecular Weight: 154.166
• Hs Code.: 2917200090
• European Community (EC) Number: 816-094-9
• NSC Number: 167610
• DSSTox Substance ID: DTXSID60304854
• Nikkaji Number: J2.618.947K
• Wikidata: Q82051119
• Mol file: 33993-24-7.mol

Synonyms:Cyclopropanecarboxylic acid anhydride;33993-24-7;cyclopropanecarboxylic anhydride;cyclopropanecarbonyl cyclopropanecarboxylate;cyclopropylcarboxylic acid anhydride;NSC167610;cyclopropanecarboxylicanhydride;SCHEMBL105221;Cyclopropanecarboxylicacidanhydride;DTXSID60304854;LZEPOJMTQYNFTR-UHFFFAOYSA-N;MFCD12404941;Cyclopropanecarboxylic acid, anhydride;AKOS006345814;NSC-167610;AS-48055;CS-0199097;FT-0721729;EN300-251861;F17603;J-019411;Cyclopropanecarboxylic acid,anhydride with cyclopropanecarboxylic acid;CYCLOPROPANECARBOXYLIC ACID, ANHYDRIDE WITH CYCLOPROPANECARBOXYLIC ACID

Chemical Property of Cyclopropanecarboxylic acid anhydride

Chemical Property:

• Vapor Pressure: 0.0181mmHg at 25°C
• Boiling Point: 253.6°Cat760mmHg
• Flash Point: 113.7°C
• PSA: 43.37000
• Density: 1.354g/cm³
• LogP: 0.87620
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 154.062994177
• Heavy Atom Count: 11
• Complexity: 179

Purity/Quality:

98%,99%, ^*data from raw suppliers

CyclopropanecarboxylicAcidAnhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C(=O)OC(=O)C2CC2

Technology Process of Cyclopropanecarboxylic acid anhydride

There total 7 articles about Cyclopropanecarboxylic acid anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ cyclopropanecarboxylic anhydride (33993-24-7)

Guidance literature:

Reference yield: 86.0%

cyclopropanecarboxylic acid chloride (4023-34-1) + cyclopropanecarboxylic acid (1759-53-1) → cyclopropanecarboxylic anhydride (33993-24-7)

Guidance literature:

cyclopropanecarboxylic acid; With triethylamine; In hexane; dichloromethane; for 1h; Cooling with ice;

cyclopropanecarboxylic acid chloride; In hexane; dichloromethane; at 20 ℃; for 2.16667h; Cooling with ice;

DOI:10.1002/adsc.201100807

Reference yield: 78.0%

Cyclopropanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester (117399-95-8) → cyclopropanecarboxylic anhydride (33993-24-7) + 2-Cyclopropylsulfanyl-pyridine (127878-53-9)

Guidance literature:

Irradiation;

DOI:10.1016/S0040-4039(00)94400-9

upstream raw materials:

cyclopropanecarboxylic acid

Cyclopropanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester

cyclopropanecarboxylic acid chloride

Downstream raw materials:

Cyclopropanecarboxylic acid 1-[6-(2-chloro-phenyl)-pyridazin-3-yl]-piperidin-4-yl ester

propene

1,2-propanediene

butadiene monoxide

Refernces

• 1、 MacHara, Ales,Werner, Lukas,Endoma-Arias, Mary Ann,Cox, D. Phillip,Hudlicky, Tomas. "Improved synthesis of buprenorphine from thebaine and/or oripavine via palladium-catalyzed N-demethylation/acylation and/or concomitant O-demethylation". experimental part. p. 613 - 626. Retrieved 2012/05/20.
• 2、 Radi, Marco,Adema, Auke D.,Daft, Jonathan R.,Cho, Jong H.,Hoebe, Eveline K.,Alexander, Lou-Ella M. M.,Peters, Godefridus J.,Chu, Chung K.. "In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs". . p. 2249 - 2253. Retrieved 2008/02/01.