1,2-trans-1-(p-(β-pyrrolidinoethoxy)phenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: 1,2-trans-1-(p-(β-pyrrolidinoethoxy)phenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene
• CAS No.: 77642-76-3
• Molecular Formula: C₃₀H₃₅NO₂
• Molecular Weight: 441.613
• Mol file: 77642-76-3.mol

Synonyms:

Chemical Property of 1,2-trans-1-(p-(β-pyrrolidinoethoxy)phenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-trans-1-(p-(β-pyrrolidinoethoxy)phenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene

There total 5 articles about 1,2-trans-1-(p-(β-pyrrolidinoethoxy)phenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) + 1-(p-hydroxyphenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene (77642-67-2,87384-08-5) → 1,2-trans-1-(p-(β-pyrrolidinoethoxy)phenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene (77642-76-3,87384-14-3)

Guidance literature:

With potassium carbonate;

Reference yield:

(E)-2-benzylidene-6-methoxy-3,4-dihydronaphthalen-1(2H)-one (50558-94-6) → 1,2-trans-1-(p-(β-pyrrolidinoethoxy)phenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene (77642-76-3,87384-14-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / H₂ / 10percent Pd-C / ethyl acetate / 760 Torr / Ambient temperature

2: 70 percent / NaBH₄

3: 43 percent / AlCl₃

4: 68 percent / K₂CO₃

With sodium tetrahydroborate; aluminium trichloride; hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate;

Reference yield:

6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 1,2-trans-1-(p-(β-pyrrolidinoethoxy)phenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene (77642-76-3,87384-14-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 68 percent / 4percent KOH / ethanol / 4 h / Ambient temperature

2: 77 percent / H₂ / 10percent Pd-C / ethyl acetate / 760 Torr / Ambient temperature

3: 70 percent / NaBH₄

4: 43 percent / AlCl₃

5: 68 percent / K₂CO₃

With potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; ethyl acetate;

upstream raw materials:

1-(2-chloroethyl)pyrrolidine hydrochloride

1-(p-hydroxyphenyl)-2-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalene

(E)-2-benzylidene-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

2-benzyl-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

Refernces