Benzo[d]isoxazol-3-yl-cyclohexyl-acetic acid 4-diethylamino-butyl ester

Base Information

• Chemical Name: Benzo[d]isoxazol-3-yl-cyclohexyl-acetic acid 4-diethylamino-butyl ester
• CAS No.: 110085-03-5
• Molecular Formula: C₂₃H₃₄N₂O₃
• Molecular Weight: 386.535
• Mol file: 110085-03-5.mol

Synonyms:

Chemical Property of Benzo[d]isoxazol-3-yl-cyclohexyl-acetic acid 4-diethylamino-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzo[d]isoxazol-3-yl-cyclohexyl-acetic acid 4-diethylamino-butyl ester

There total 4 articles about Benzo[d]isoxazol-3-yl-cyclohexyl-acetic acid 4-diethylamino-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-(N,N-diethylamino)-1-butanol (2683-56-9) + α-cyclohexyl-1,2-benzisoxazole-3-acetic acid (89245-59-0) → Benzo[d]isoxazol-3-yl-cyclohexyl-acetic acid 4-diethylamino-butyl ester (110085-03-5)

Guidance literature:

With triethylamine; p-toluenesulfonyl chloride; In toluene; 1.) 1 h, RT; 2.) 3 h, 70 deg C;

DOI:10.1248/cpb.35.2095

Reference yield:

Cyclohexyl iodide (626-62-0) → Benzo[d]isoxazol-3-yl-cyclohexyl-acetic acid 4-diethylamino-butyl ester (110085-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 33 percent / 60 percent NaH / dimethylformamide; paraffin / 0.5 h / Ambient temperature

2: 84 percent / NaOH / H₂O; ethanol / 0.5 h / 60 °C

3: 47 percent / p-toluenesulfonyl chloride, triethylamine / toluene / 1.) 1 h, RT; 2.) 3 h, 70 deg C

With sodium hydroxide; sodium hydride; triethylamine; p-toluenesulfonyl chloride; In ethanol; water; N,N-dimethyl-formamide; toluene; paraffin;

DOI:10.1248/cpb.35.2095

Reference yield:

methyl α-cyclohexyl-1,2-benzisoxazole-3-acetate (89245-60-3) → Benzo[d]isoxazol-3-yl-cyclohexyl-acetic acid 4-diethylamino-butyl ester (110085-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaOH / H₂O; ethanol / 0.5 h / 60 °C

2: 47 percent / p-toluenesulfonyl chloride, triethylamine / toluene / 1.) 1 h, RT; 2.) 3 h, 70 deg C

With sodium hydroxide; triethylamine; p-toluenesulfonyl chloride; In ethanol; water; toluene;

DOI:10.1248/cpb.35.2095

upstream raw materials:

4-(N,N-diethylamino)-1-butanol

α-cyclohexyl-1,2-benzisoxazole-3-acetic acid

Cyclohexyl iodide

methyl α-cyclohexyl-1,2-benzisoxazole-3-acetate

Refernces