Technology Process of C27H22N2O2
There total 3 articles about C27H22N2O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C26H22N2O;
With
n-butyllithium;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
N,N-dimethyl-formamide;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 3h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
DOI:10.1039/c2jm33228k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / 85 °C
2.1: XPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 24 h / Reflux
3.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C
3.2: 3 h / -78 - 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); n-butyllithium; toluene-4-sulfonic acid; sodium t-butanolate; XPhos;
In
tetrahydrofuran; toluene;
1.1: |Fischer Indole Synthesis / 2.1: |Buchwald-Hartwig Coupling;
DOI:10.1039/c2jm33228k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: XPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 24 h / Reflux
2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C
2.2: 3 h / -78 - 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); n-butyllithium; sodium t-butanolate; XPhos;
In
tetrahydrofuran; toluene;
1.1: |Buchwald-Hartwig Coupling;
DOI:10.1039/c2jm33228k