Technology Process of 1-(5-O-Benzoyl-2,3-dideoxy-2-fluoro-α-D-threo-pentofuranosyl)cytosine
There total 7 articles about 1-(5-O-Benzoyl-2,3-dideoxy-2-fluoro-α-D-threo-pentofuranosyl)cytosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 64 percent / K2CO3 / tetrahydrofuran / 36 h / Ambient temperature
2: 78 percent / pyridine / CH2Cl2 / 0.75 h / -30 - -10 °C
3: 1) NaH / 1) DMF, 0 deg C, 30 min, 2a) 0 deg C, 20 min, b) to r.t. over 30 min
4: 86 percent / Bu3SnH, 2,2'-azobis(2-methylpropionitrile) / toluene / 3 h / Heating
5: HBr, AcOH / CH2Cl2 / 3 h / Ambient temperature
6: 1,2-dichloro-ethane / 4 h / Heating
With
pyridine; 2,2'-azobis(isobutyronitrile); hydrogen bromide; tri-n-butyl-tin hydride; sodium hydride; potassium carbonate; acetic acid;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97 percent / HBr, AcOH / CH2Cl2 / 24 h / Ambient temperature
2: 64 percent / K2CO3 / tetrahydrofuran / 36 h / Ambient temperature
3: 78 percent / pyridine / CH2Cl2 / 0.75 h / -30 - -10 °C
4: 1) NaH / 1) DMF, 0 deg C, 30 min, 2a) 0 deg C, 20 min, b) to r.t. over 30 min
5: 86 percent / Bu3SnH, 2,2'-azobis(2-methylpropionitrile) / toluene / 3 h / Heating
6: HBr, AcOH / CH2Cl2 / 3 h / Ambient temperature
7: 1,2-dichloro-ethane / 4 h / Heating
With
pyridine; 2,2'-azobis(isobutyronitrile); hydrogen bromide; tri-n-butyl-tin hydride; sodium hydride; potassium carbonate; acetic acid;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 78 percent / pyridine / CH2Cl2 / 0.75 h / -30 - -10 °C
2: 1) NaH / 1) DMF, 0 deg C, 30 min, 2a) 0 deg C, 20 min, b) to r.t. over 30 min
3: 86 percent / Bu3SnH, 2,2'-azobis(2-methylpropionitrile) / toluene / 3 h / Heating
4: HBr, AcOH / CH2Cl2 / 3 h / Ambient temperature
5: 1,2-dichloro-ethane / 4 h / Heating
With
pyridine; 2,2'-azobis(isobutyronitrile); hydrogen bromide; tri-n-butyl-tin hydride; sodium hydride; acetic acid;
In
dichloromethane; 1,2-dichloro-ethane; toluene;