Technology Process of (+)-<(2R,3R,4R)-4-(t-Butyldimethylsiloxy)tetrahydropyran-2-yl>acetonitrile
There total 7 articles about (+)-<(2R,3R,4R)-4-(t-Butyldimethylsiloxy)tetrahydropyran-2-yl>acetonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: H2 / 5percent Pd-activated carbon / methanol / 4 h / Ambient temperature
2: NaOMe / methanol / 2 h / Ambient temperature
3: ZnCl2 / 3 h / 80 °C
4: 97 percent / imidazole / dimethylformamide / 18 h / Ambient temperature
5: iBu2AlH / toluene; CH2Cl2 / 3 h / Ambient temperature
6: 4-(dimethylamino)pyridine, pyridine / CH2Cl2 / 48 h / Ambient temperature
7: NaI / dimethylsulfoxide / 5 h / 50 °C
With
pyridine; 1H-imidazole; dmap; hydrogen; sodium methylate; diisobutylaluminium hydride; sodium iodide; zinc(II) chloride;
palladium on activated charcoal;
In
methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
With
sodium iodide;
In
dimethyl sulfoxide;
at 50 ℃;
for 5h;
Yield given;
-
-
20072-97-3,33428-78-3,75800-66-7,75800-68-9,78854-43-0,89919-60-8,126638-07-1,126638-08-2
(2S,3S,4R)-Tetrahydro-pyran-2,3,4-triol
- Guidance literature:
-
Multi-step reaction with 5 steps
1: ZnCl2 / 3 h / 80 °C
2: 97 percent / imidazole / dimethylformamide / 18 h / Ambient temperature
3: iBu2AlH / toluene; CH2Cl2 / 3 h / Ambient temperature
4: 4-(dimethylamino)pyridine, pyridine / CH2Cl2 / 48 h / Ambient temperature
5: NaI / dimethylsulfoxide / 5 h / 50 °C
With
pyridine; 1H-imidazole; dmap; diisobutylaluminium hydride; sodium iodide; zinc(II) chloride;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;