Technology Process of (Z)-2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N'-hydroxyacetimidamide
There total 7 articles about (Z)-2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N'-hydroxyacetimidamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; potassium carbonate;
In
ethanol;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate; potassium iodide / acetone / 2 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Reflux
3.1: water; lithium hydroxide monohydrate / isopropyl alcohol / 2 h / 20 °C
4.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 0.5 h / Cooling with ice
4.2: 0.17 h / Cooling with ice
5.1: trifluoroacetic anhydride / tetrahydrofuran / 0.17 h / -15 °C / Inert atmosphere
6.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 12 h / 20 °C
With
thionyl chloride; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; potassium iodide;
In
tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate; potassium iodide / acetone / 2 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Reflux
3.1: water; lithium hydroxide monohydrate / isopropyl alcohol / 2 h / 20 °C
4.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 0.5 h / Cooling with ice
4.2: 0.17 h / Cooling with ice
5.1: trifluoroacetic anhydride / tetrahydrofuran / 0.17 h / -15 °C / Inert atmosphere
6.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 12 h / 20 °C
With
thionyl chloride; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; potassium iodide;
In
tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; acetone;