1-hydroxy-2-[1-(2-hydroxyethyl)-4,5-dihydro-1H-imidazol-2-yl]-1-oxodiazanium

Base Information

• Chemical Name: 1-hydroxy-2-[1-(2-hydroxyethyl)-4,5-dihydro-1H-imidazol-2-yl]-1-oxodiazanium
• CAS No.: 6266-34-8
• Molecular Formula: C₅H₁₀N₄O₃
• Molecular Weight: 174.159
• Mol file: 6266-34-8.mol

Synonyms:2-Imidazoline-1-ethanol,2-nitramino- (6CI); NSC 36875

Chemical Property of 1-hydroxy-2-[1-(2-hydroxyethyl)-4,5-dihydro-1H-imidazol-2-yl]-1-oxodiazanium

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-hydroxy-2-[1-(2-hydroxyethyl)-4,5-dihydro-1H-imidazol-2-yl]-1-oxodiazanium

There total 3 articles about 1-hydroxy-2-[1-(2-hydroxyethyl)-4,5-dihydro-1H-imidazol-2-yl]-1-oxodiazanium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Methyl-N'-nitro-N-nitrosoguanidine (70-25-7) + 2-(2-Aminoethylamino)ethanol (111-41-1) → 2-(2-nitroamino-4,5-dihydro-imidazol-1-yl)-ethanol (6266-34-8)

Guidance literature:

DOI:10.1021/ja01583a065

Reference yield:

→ 1(2-hydroxyethyl)-2-nitroiminoimidazolidine (6266-34-8)

Guidance literature:

Reference yield:

→ 2-(2-nitroamino-4,5-dihydro-imidazol-1-yl)-ethanol (6266-34-8)

Guidance literature:

nach McKay et al.;

DOI:10.1021/jm50010a005

upstream raw materials:

N-Methyl-N'-nitro-N-nitrosoguanidine

2-(2-Aminoethylamino)ethanol

Downstream raw materials:

2-(2-benzylamino-4,5-dihydro-imidazol-1-yl)-ethanol

1-nitro-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole

1-(2-Chlor-ethyl)-2-nitramino-2-imidazolin

1-benzyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole

Refernces

• 1、 SKINNER,GRAM,GREENE,GREENBERG,BAKER. "Potential anticancer agents. XXXI. The relationship of chemical structure to antileukaemic activity with analogues of 1-methyl-3-nitro-1-nitrosoguanidine (NSC-9369).". . p. 299 - 333. Retrieved 2007/10/04.