Technology Process of methyl 12(S)-<(tert-butyldiphenulsilyl)oxy>-14,14-bis(ethylthio)-5(Z),8(Z),10(E)-tetradecatrienoate
There total 8 articles about methyl 12(S)-<(tert-butyldiphenulsilyl)oxy>-14,14-bis(ethylthio)-5(Z),8(Z),10(E)-tetradecatrienoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 92.6 percent / imidazole / dimethylformamide / 18 h / 75 - 80 °C
2: 86 percent / trifluoroacetic acid / tetrahydrofuran; H2O / 6 h / Ambient temperature
3: 76.8 percent / sodium periodate / tetrahydrofuran; H2O; acetone / 0.25 h / Ambient temperature
4: 79 percent / benzene / 6.5 h / 70 °C
5: tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 deg C, 1 h, 2.) RT, 1 h
6: sodium bicarbonate / 0.5 h / Ambient temperature
With
1H-imidazole; sodium periodate; sodium hydrogencarbonate; trifluoroacetic acid;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jo00375a009
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 79 percent / benzene / 6.5 h / 70 °C
2: tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 deg C, 1 h, 2.) RT, 1 h
3: sodium bicarbonate / 0.5 h / Ambient temperature
With
sodium hydrogencarbonate;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; benzene;
DOI:10.1021/jo00375a009
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 76.8 percent / sodium periodate / tetrahydrofuran; H2O; acetone / 0.25 h / Ambient temperature
2: 79 percent / benzene / 6.5 h / 70 °C
3: tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 deg C, 1 h, 2.) RT, 1 h
4: sodium bicarbonate / 0.5 h / Ambient temperature
With
sodium periodate; sodium hydrogencarbonate;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; acetone; benzene;
DOI:10.1021/jo00375a009
![1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-bis-ethylsulfanyl-propan-1-ol](/Databaselist/images/loading.webp)
