cis-N-(2-methylcyclohexyl)morpholine

Base Information

• Chemical Name: cis-N-(2-methylcyclohexyl)morpholine
• CAS No.: 96835-74-4
• Molecular Formula: C₁₁H₂₁NO
• Molecular Weight: 183.294
• Mol file: 96835-74-4.mol

Synonyms:

Chemical Property of cis-N-(2-methylcyclohexyl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-N-(2-methylcyclohexyl)morpholine

There total 5 articles about cis-N-(2-methylcyclohexyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-Methyl-cyclohexylidene)-morpholin-4-ium; chloride (86822-52-8) → trans-N-(2-methylcyclohexyl)morpholine (64760-75-4) + cis-N-(2-methylcyclohexyl)morpholine (64760-74-3,64760-75-4,96835-74-4)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at 25 ℃; for 24h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00168a009

Reference yield:

6-methyl-1-(4-morpholinyl)cyclohexene (5292-69-3) → trans-N-(2-methylcyclohexyl)morpholine (64760-75-4) + cis-N-(2-methylcyclohexyl)morpholine (64760-74-3,64760-75-4,96835-74-4)

Guidance literature:

With diisopropylamine borane; In acetic acid; at 25 ℃; for 24h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00168a009

Reference yield:

2-Methylcyclohexanone (583-60-8) → cis-N-(2-methylcyclohexyl)morpholine (64760-74-3,64760-75-4,96835-74-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / p-toluenesulfonic acid / benzene / Heating

2: 95 percent / HCl-gas / diethyl ether

3: (CH₃)3CNH₂BH₃ / acetic acid / 24 h / 25 °C

With hydrogenchloride; N-tert-butylaminoborane; toluene-4-sulfonic acid; In diethyl ether; acetic acid; benzene;

DOI:10.1021/jo00168a009

upstream raw materials:

2-methyl-1-morpholinocyclohexene

4-(2-Methyl-cyclohexylidene)-morpholin-4-ium; chloride

6-methyl-1-(4-morpholinyl)cyclohexene

2-Methylcyclohexanone

Refernces