ethyl 2-methyl-3-(3-indolyl)acrylate

Base Information

• Chemical Name: ethyl 2-methyl-3-(3-indolyl)acrylate
• CAS No.: 214541-54-5
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.279
• Mol file: 214541-54-5.mol

Synonyms:

Chemical Property of ethyl 2-methyl-3-(3-indolyl)acrylate

Chemical Property:

• Boiling Point: 399.7±17.0 °C(Predicted)
• Density: 1.171±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl3-(3-Indolyl)-2-methylacrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-methyl-3-(3-indolyl)acrylate

There total 1 articles about ethyl 2-methyl-3-(3-indolyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → ethyl 2-methyl-3-(3-indolyl)acrylate (214541-54-5)

Guidance literature:

With triphenylphosphine; Yield given; Multistep reaction; 2.) benzene, reflux, 4 h;

DOI:10.1021/jf980205f

Reference yield: 95.8%

ethyl 2-methyl-3-(3-indolyl)acrylate (214541-54-5) → ethyl 3-(1H-indol-3-yl)-2-methylpropanoate (57901-11-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h; under 760 Torr; Ambient temperature;

DOI:10.1021/jf980205f

Reference yield:

ethyl 2-methyl-3-(3-indolyl)acrylate (214541-54-5) → rac-3-(1H-indol-3-yl)-2-methylpropanoic acid (15142-91-3,69088-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95.8 percent / H₂ / 5 percent Pd/C / methanol / 1 h / 760 Torr / Ambient temperature

2: 60.7 percent / 5 percent aq. NaOH / ethanol / 2 h / Heating

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jf980205f

upstream raw materials:

Indole-3-carboxaldehyde

Ethyl 2-bromopropionate

Downstream raw materials:

ethyl 3-(1H-indol-3-yl)-2-methylpropanoate

rac-3-(1H-indol-3-yl)-2-methylpropanoic acid

Refernces