4-diphenylphosphinylbenzenecarboxylic acid 4-[N-(3-trimethoxysilylpropyl)amide]

Base Information

• Chemical Name: 4-diphenylphosphinylbenzenecarboxylic acid 4-[N-(3-trimethoxysilylpropyl)amide]
• CAS No.: 1160705-20-3
• Molecular Formula: C₂₅H₃₀NO₄PSi
• Molecular Weight: 467.577
• Mol file: 1160705-20-3.mol

Synonyms:

Chemical Property of 4-diphenylphosphinylbenzenecarboxylic acid 4-[N-(3-trimethoxysilylpropyl)amide]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-diphenylphosphinylbenzenecarboxylic acid 4-[N-(3-trimethoxysilylpropyl)amide]

There total 2 articles about 4-diphenylphosphinylbenzenecarboxylic acid 4-[N-(3-trimethoxysilylpropyl)amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 4-benzhydrylbenzoate (34823-78-4) + 3-(trimethoxysilyl)propan-1-amine (13822-56-5) → 4-diphenylphosphinylbenzenecarboxylic acid 4-[N-(3-trimethoxysilylpropyl)amide] (1160705-20-3)

Guidance literature:

With sodium methylate; at 170 ℃; for 4h; Inert atmosphere; neat (no solvent);

DOI:10.1039/b820449g

Reference yield:

3-(trimethoxysilyl)propan-1-amine (13822-56-5) + methyl 4-(diphenylphosphino)benzoate (5032-51-9) → 4-diphenylphosphinylbenzenecarboxylic acid 4-[N-(3-trimethoxysilylpropyl)amide] (1160705-20-3)

Guidance literature:

With sodium methylate; at 170 ℃; for 4h;

DOI:10.1002/adsc.200900698

Reference yield: 99.0%

bis(benzonitrile)palladium(II) dichloride (15617-18-2,39958-10-6,14220-64-5) + 4-diphenylphosphinylbenzenecarboxylic acid 4-[N-(3-trimethoxysilylpropyl)amide] (1160705-20-3) → dichloridobis(4-diphenylphosphinylbenzenecarboxylicacid-4N-(3-trimethoxysilylpropyl)amide)palladium(II) (1160705-21-4)

Guidance literature:

In dichloromethane; Pd-complex dissolved in CH2Cl2, added to soln. of ligand in CH2Cl2, stirred for 4 h at room temp.; filtered, filtrate evapd. to dryness under reduced pressure, residue washed with ether; elem. anal.;

DOI:10.1039/b820449g

upstream raw materials:

methyl 4-benzhydrylbenzoate

3-(trimethoxysilyl)propan-1-amine

methyl 4-(diphenylphosphino)benzoate

Downstream raw materials:

dichloridobis(4-diphenylphosphinylbenzenecarboxylicacid-4N-(3-trimethoxysilylpropyl)amide)palladium(II)

C₆₀H₇₅ClN₂O₈P₂RuSi₂

Refernces

• 1、 Wang, Lei,Reis, Andreas,Seifert, Andreas,Philippi, Thomas,Ernst, Stefan,Jia, Mingjun,Thiel, Werner R.. "A simple procedure for the covalent grafting of triphenylphosphine ligands on silica: Application in the palladium catalyzed Suzuki reaction". experimental part. p. 3315 - 3320. Retrieved 2009/08/08.