Technology Process of 3-ethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid
There total 1 articles about 3-ethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.166667h;
ethyl iodide;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 3h;
DOI:10.1021/jm401456d
- Guidance literature:
-
3-ethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.166667h;
3-ethyl-N,4-dihydroxy-5-methylbenzimidamide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 18h;
DOI:10.1021/jm401456d
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 18 h / 20 °C
2.1: sodium hydroxide / isopropyl alcohol; water / 20 h / 20 °C
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm401456d
![4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid](/Databaselist/images/loading.webp)
