1-ethyl-2-(4-hydroxy-phenyl)-indan-5-ol

Base Information

• Chemical Name: 1-ethyl-2-(4-hydroxy-phenyl)-indan-5-ol
• CAS No.: 77799-27-0
• Molecular Formula: C₁₇H₁₈O₂
• Molecular Weight: 254.329
• Mol file: 77799-27-0.mol

Synonyms:

Chemical Property of 1-ethyl-2-(4-hydroxy-phenyl)-indan-5-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethyl-2-(4-hydroxy-phenyl)-indan-5-ol

There total 4 articles about 1-ethyl-2-(4-hydroxy-phenyl)-indan-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-methoxyphenyl)-2-(4-methoxyphenyl)propanoic acid (33902-36-2) → 1-ethyl-2-(4-hydroxy-phenyl)-indan-5-ol (77799-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: P₂O₅; benzene

2: diethyl ether; benzene / anschliessendes Behandeln mit wss. HCl

3: methanol; palladium / Hydrogenation_.Kochen des Reaktionsprodukts mit Essigsaeure und wss. HBr

With methanol; diethyl ether; phosphorus pentoxide; palladium; benzene;

DOI:10.1021/ja01252a034

Reference yield:

2-(4-methoxyphenyl)-5-methoxy-1-indanone (7478-21-9) → 1-ethyl-2-(4-hydroxy-phenyl)-indan-5-ol (77799-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; benzene / anschliessendes Behandeln mit wss. HCl

2: methanol; palladium / Hydrogenation_.Kochen des Reaktionsprodukts mit Essigsaeure und wss. HBr

With methanol; diethyl ether; palladium; benzene;

DOI:10.1021/ja01192a066 DOI:10.1021/ja01252a034

Reference yield:

3-ethyl-6-methoxy-2-(4-methoxy-phenyl)-indene (872786-19-1) → 1-ethyl-2-(4-hydroxy-phenyl)-indan-5-ol (77799-27-0)

Guidance literature:

With methanol; palladium; Hydrogenation_.Kochen des Reaktionsprodukts mit Essigsaeure und wss. HBr;

DOI:10.1021/ja01192a066 DOI:10.1021/ja01252a034

upstream raw materials:

3-ethyl-6-methoxy-2-(4-methoxy-phenyl)-indene

2-(4-methoxyphenyl)-5-methoxy-1-indanone

3-(3-methoxyphenyl)-2-(4-methoxyphenyl)propanoic acid

sodium 2-(4-methoxyphenyl)acetate