O,O-dibenzoyltyrosol

Base Information

• Chemical Name: O,O-dibenzoyltyrosol
• CAS No.: 74447-32-8
• Molecular Formula: C₂₂H₁₈O₄
• Molecular Weight: 346.383
• Mol file: 74447-32-8.mol

Synonyms:

Chemical Property of O,O-dibenzoyltyrosol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O,O-dibenzoyltyrosol

There total 15 articles about O,O-dibenzoyltyrosol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyloxybenzyl alcohol (836-43-1) → O,O-dibenzoyltyrosol (74447-32-8)

Guidance literature:

Multi-step reaction with 9 steps

1: 3.1 g / thionyl chloride / diethyl ether / 2 h / Heating

2: 4.2 g / n-butyl-lithium / hexane; tetrahydrofuran / 1.) -23 deg C, 1.5 h, 2.) 0 deg C, 14 h

3: 3.6 g / mercuric oxide, mercuric chloride / acetonitrile / 6 h / Heating

4: 1.) Raney nickel, 2.) hydrogen / 2.) palladium on charcoal / 1.) ethanol, reflux, 15 - 20 min, 2.) methanol,

5: 2.5 g / triethylamine / CH₂Cl₂ / 0.17 h / 0 - 10 °C

6: 1.12 g / aq. hydrochloric acid / tetrahydrofuran / 0.67 h / 18 °C

7: 1.83 g / sodium borohydride / methanol / 0.17 h / Ambient temperature

8: sodium hydroxide / methanol; H₂O / 1 h / 70 °C

9: 48 mg / pyridine / 18 h / 0 °C

With pyridine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; hydrogen; nickel; triethylamine; mercury dichloride; mercury(II) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; acetonitrile;

Reference yield:

1-azido-2-(4-hydroxyphenyl)ethane (74447-34-0) → O,O-dibenzoyltyrosol (74447-32-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 828 mg / potassium carbonate / methanol / Heating

2: 1.) lithium aluminium hydride, 2.) ethereal hydrogen chloride / 1.) ether, reflux, 1 h, 2.) methanol

3: 1.) hydrogen, 2.) ethereal hydrogen chloride / 1.) palladium-charcoal / 1.) methanol, 2.) ethanol

4: 7 mg / NAD+, ethanol, liver alcohol dehydrogenase, pea seedling diamine oxidase, phosphate buffer (pH 8), catalase / 32 h / 37 °C / further catalysts

5: 48 mg / pyridine / 18 h / 0 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; phosphate buffer; ethanol; liver alcohol dehydrogenase; pea seedling diamine oxidase; NAD; hydrogen; potassium carbonate; catalase; palladium on activated charcoal; In methanol;

Reference yield:

1-azido-2-(4-methylsulphonyloxyphenyl)ethane (74447-35-1) → O,O-dibenzoyltyrosol (74447-32-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 310 mg / sodium hydroxide / methanol; H₂O / 1 h / 70 °C

2: 828 mg / potassium carbonate / methanol / Heating

3: 1.) lithium aluminium hydride, 2.) ethereal hydrogen chloride / 1.) ether, reflux, 1 h, 2.) methanol

4: 1.) hydrogen, 2.) ethereal hydrogen chloride / 1.) palladium-charcoal / 1.) methanol, 2.) ethanol

5: 7 mg / NAD+, ethanol, liver alcohol dehydrogenase, pea seedling diamine oxidase, phosphate buffer (pH 8), catalase / 32 h / 37 °C / further catalysts

6: 48 mg / pyridine / 18 h / 0 °C

With pyridine; hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; phosphate buffer; ethanol; liver alcohol dehydrogenase; pea seedling diamine oxidase; NAD; hydrogen; potassium carbonate; catalase; palladium on activated charcoal; In methanol; water;

upstream raw materials:

p-hydroxyphenethyl alcohol

benzoyl chloride

4-benzyloxybenzyl alcohol

tyramine hydrochloride

Refernces