(3beta)-30-hydroxy-11,30-dioxoolean-12-en-3-yl beta-D-glucopyranosiduronic acid

Base Information

• Chemical Name: (3beta)-30-hydroxy-11,30-dioxoolean-12-en-3-yl beta-D-glucopyranosiduronic acid
• CAS No.: 147218-57-3
• Molecular Formula: C₃₆H₅₄O₁₀
• Molecular Weight: 646.819
• Mol file: 147218-57-3.mol

Synonyms:

Chemical Property of (3beta)-30-hydroxy-11,30-dioxoolean-12-en-3-yl beta-D-glucopyranosiduronic acid

Chemical Property:

• Vapor Pressure: 1.78E-28mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3beta)-30-hydroxy-11,30-dioxoolean-12-en-3-yl beta-D-glucopyranosiduronic acid

There total 27 articles about (3beta)-30-hydroxy-11,30-dioxoolean-12-en-3-yl beta-D-glucopyranosiduronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

β-glycyrrhizin → 1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid (34096-83-8,147218-57-3)

Guidance literature:

With Pectinex Ultra SP-L; In water; at 40 ℃; for 216h;

Reference yield: 95.0%

18α-glycyrrhizic acid → glycyrrhetic acid 3-O-mono-β-D-glucuronide (147218-57-3)

Guidance literature:

With sodium hydroxide; Cryptococcus magnus MG-27; In water; at 45 ℃; for 48h;

DOI:10.1271/bbb.58.455

Reference yield: 93.5%

methanol (67-56-1) + methyl 1-(18β-glycyrrhet-3-yl)-2',3',4'-tri-O-acetyl-β-D-glucopyranuronate (27821-74-5,69465-31-2) → 1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid (34096-83-8,147218-57-3)

Guidance literature:

With potassium hydroxide; for 2h; Ambient temperature;

upstream raw materials:

methanol

methyl 1-(18β-glycyrrhet-3-yl)-2',3',4'-tri-O-acetyl-β-D-glucopyranuronate

apioglycyrrhizin

methyl glycyrrhetinate

Downstream raw materials:

18-α-glycyrrhetinic acid

Refernces

• 1、 Kim, Dong-Hyun,Jang, Il-Sung,Lee, Seung-Won. "Bacteroides J-37, a human intestinal bacterium, produces α- glucuronidase". . p. 834 - 837. Retrieved 1997.
• 2、 Imai, Teruko,Sakai, Michinori,Ohtake, Hiroshi,Azuma, Hidekazu,Otagiri, Masaki. "In vitro and in vivo evaluation of the enhancing activity of glycyrrhizin on the intestinal absorption of drugs". . p. 80 - 86. Retrieved 1999.
• 3、 Wu, Xiuhong,Wang, Shaoyan,Zhang, Lina,Wu, Lidong,Chen, Yi. "Thermally controlled biotransformation of glycyrrhizic acid via an asymmetric temperature-responsive polyurethane membrane". . p. 34823 - 34829. Retrieved 2018.
• 4、 -. "Chemical synthesis method of glycyrrtinic acid 3-O-mono-beta-D-glucuronide (GAMG)". . . Retrieved 2019/01/08.