Technology Process of 2-(4-Fluoro-phenyl)-2-{4-[(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-ethanol
There total 14 articles about 2-(4-Fluoro-phenyl)-2-{4-[(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 28.0 g / potassium carbonate / H2O / 3 h / Ambient temperature
2: 28.1 g / sodium borohydride / methanol / 6 h / Ambient temperature
3: 9.4 g / various solvent(s) / 120 h / 45 °C
4: 8.4 g / potassium carbonate / methanol / 3 h / Ambient temperature
5: 0.88 g / hydrogen / 10percent Pd/C / propan-2-ol / 1 h / Ambient temperature
6: 0.18 g / propan-2-ol / 2 h / Heating
With
sodium tetrahydroborate; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
methanol; water; isopropyl alcohol;
DOI:10.1016/S0957-4166(00)80531-5
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 28.1 g / sodium borohydride / methanol / 6 h / Ambient temperature
2: 9.4 g / various solvent(s) / 120 h / 45 °C
3: 8.4 g / potassium carbonate / methanol / 3 h / Ambient temperature
4: 0.88 g / hydrogen / 10percent Pd/C / propan-2-ol / 1 h / Ambient temperature
5: 0.18 g / propan-2-ol / 2 h / Heating
With
sodium tetrahydroborate; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
methanol; isopropyl alcohol;
DOI:10.1016/S0957-4166(00)80531-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 9.4 g / various solvent(s) / 120 h / 45 °C
2: 8.4 g / potassium carbonate / methanol / 3 h / Ambient temperature
3: 0.88 g / hydrogen / 10percent Pd/C / propan-2-ol / 1 h / Ambient temperature
4: 0.18 g / propan-2-ol / 2 h / Heating
With
hydrogen; potassium carbonate;
palladium on activated charcoal;
In
methanol; isopropyl alcohol;
DOI:10.1016/S0957-4166(00)80531-5