Technology Process of C35H21F3N4O2
There total 10 articles about C35H21F3N4O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; tert-butyl XPhos;
In
1,4-dioxane;
at 100 ℃;
for 4h;
DOI:10.1016/j.bmcl.2011.04.129
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / ethanol / 4 h / 40 °C
2: manganese(IV) oxide / dichloromethane / 2 h / 20 °C
3: potassium carbonate / ethanol / 12 h / 100 °C
4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane / 2 h / 80 °C
5: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; tert-butyl XPhos / 1,4-dioxane / 4 h / 100 °C
With
manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; sodium carbonate; potassium carbonate; tert-butyl XPhos;
In
1,4-dioxane; ethanol; dichloromethane;
4: Suzuki coupling / 5: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.04.129
- Guidance literature:
-
Multi-step reaction with 4 steps
1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C
2: potassium carbonate / ethanol / 12 h / 100 °C
3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane / 2 h / 80 °C
4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; tert-butyl XPhos / 1,4-dioxane / 4 h / 100 °C
With
manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; potassium carbonate; tert-butyl XPhos;
In
1,4-dioxane; ethanol; dichloromethane;
3: Suzuki coupling / 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.04.129