Technology Process of 7-[(1R,5R)-2-Oxo-5-((E)-3-oxo-oct-1-enyl)-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-heptanoic acid
There total 7 articles about 7-[(1R,5R)-2-Oxo-5-((E)-3-oxo-oct-1-enyl)-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-heptanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 18.1 g / conc. hydrochloric acid / 1.5 h / 55 °C
2: 4.4 g / di-isobutylaluminium hydride / benzene; diethyl ether / 0.25 h / 10 °C
3: 2.) chromium trioxide, conc. sulphuric acid / 1.) THF, reflux, 20 h, 2.) DMF, 15 deg C, 1.5 h
With
chromium(VI) oxide; hydrogenchloride; diisobutylaluminum hydride; sulfuric acid;
In
diethyl ether; benzene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 25.5 g / aq. sodium hydroxide, hydrogen peroxide / methanol / 1.) 10 deg C, 2.) room temperature, 18 h
2: 33 g / 10 h / Heating
3: 35.3 g / sodium carbonate / methanol; H2O / 4.5 h / Heating
4: 18.1 g / conc. hydrochloric acid / 1.5 h / 55 °C
5: 4.4 g / di-isobutylaluminium hydride / benzene; diethyl ether / 0.25 h / 10 °C
6: 2.) chromium trioxide, conc. sulphuric acid / 1.) THF, reflux, 20 h, 2.) DMF, 15 deg C, 1.5 h
With
chromium(VI) oxide; hydrogenchloride; sodium hydroxide; diisobutylaluminum hydride; sulfuric acid; dihydrogen peroxide; sodium carbonate;
In
methanol; diethyl ether; water; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 35.3 g / sodium carbonate / methanol; H2O / 4.5 h / Heating
2: 18.1 g / conc. hydrochloric acid / 1.5 h / 55 °C
3: 4.4 g / di-isobutylaluminium hydride / benzene; diethyl ether / 0.25 h / 10 °C
4: 2.) chromium trioxide, conc. sulphuric acid / 1.) THF, reflux, 20 h, 2.) DMF, 15 deg C, 1.5 h
With
chromium(VI) oxide; hydrogenchloride; diisobutylaluminum hydride; sulfuric acid; sodium carbonate;
In
methanol; diethyl ether; water; benzene;