Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-methylphenylazo)malonate

Base Information

• Chemical Name: Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-methylphenylazo)malonate
• CAS No.: 131843-64-6
• Molecular Formula: C₁₅H₁₈ClN₃O₅
• Molecular Weight: 355.778
• Mol file: 131843-64-6.mol

Synonyms:

Chemical Property of Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-methylphenylazo)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-methylphenylazo)malonate

There total 3 articles about Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-methylphenylazo)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl [benzyl(methyl)amino]propanedioate (5417-21-0) → Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-methylphenylazo)malonate (131843-64-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / H₂ / 10percent Pd/C / methanol / 2.5 h / 20 °C

2: 91 percent / CH₂Cl₂ / 18 h / Heating

3: 1.) 5 M aq. NaNO₂, HOAc, conc. HCl, 2.) aq. K₂CO₃ / 1.) 15 min, 5 deg C, 2.) H₂O, acetone, 1 h, 10 deg C

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; sodium nitrite; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/hlca.19900730615

Reference yield:

Dimethyl 2-(Methylamino)malonate Hydrochloride (98549-18-9) → Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-methylphenylazo)malonate (131843-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / CH₂Cl₂ / 18 h / Heating

2: 1.) 5 M aq. NaNO₂, HOAc, conc. HCl, 2.) aq. K₂CO₃ / 1.) 15 min, 5 deg C, 2.) H₂O, acetone, 1 h, 10 deg C

With hydrogenchloride; potassium carbonate; acetic acid; sodium nitrite; In dichloromethane;

DOI:10.1002/hlca.19900730615

Reference yield:

Dimethyl 2-(2-Chloro-N-methylacetamido)malonate (131843-54-4) + p-toluidine (106-49-0,12221-03-3) → Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-methylphenylazo)malonate (131843-64-6)

Guidance literature:

With hydrogenchloride; potassium carbonate; acetic acid; sodium nitrite; Yield given. Multistep reaction; 1.) 15 min, 5 deg C, 2.) H₂O, acetone, 1 h, 10 deg C;

DOI:10.1002/hlca.19900730615

upstream raw materials:

Dimethyl 2-(2-Chloro-N-methylacetamido)malonate

p-toluidine

dimethyl [benzyl(methyl)amino]propanedioate

Dimethyl 2-(Methylamino)malonate Hydrochloride

Refernces