1H-Benzimidazole, 2-cyclohexyl-1-methyl-

Base Information

• Chemical Name: 1H-Benzimidazole, 2-cyclohexyl-1-methyl-
• CAS No.: 106380-62-5
• Molecular Formula: C14H18N2
• Molecular Weight: 214.31
• Mol file: 106380-62-5.mol

Synonyms:

Chemical Property of 1H-Benzimidazole, 2-cyclohexyl-1-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole, 2-cyclohexyl-1-methyl-

There total 16 articles about 1H-Benzimidazole, 2-cyclohexyl-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclohexane carbonitrile (766-05-2) + N-methyl-1,2-phenylenediamine (4760-34-3) → 2-cyclohexyl-1-methyl-1H-benzo[d]imidazole (106380-62-5)

Guidance literature:

With sodium hydride; In toluene; mineral oil; at 120 ℃; for 3h;

DOI:10.1055/s-0028-1087383

Reference yield: 80.0%

1-bromocyclohexane (108-85-0) + 1-Methylbenzimidazole (1632-83-3) → 2-cyclohexyl-1-methyl-1H-benzo[d]imidazole (106380-62-5)

Guidance literature:

With {Au(dppm)}2Cl₂; trifluoroacetic acid; In methanol; Inert atmosphere; UV-irradiation;

DOI:10.1039/c6sc00807k

Reference yield: 71.0%

N-methyl-1,2-phenylenediamine (4760-34-3) → 2-cyclohexyl-1-methyl-1H-benzo[d]imidazole (106380-62-5) + cyclohexane carboxylic acid (2-methylamino-phenyl)-amide

Guidance literature:

N-methyl-1,2-phenylenediamine; With trimethylaluminum chloride; In toluene; at 0 - 20 ℃;

hydroxymethyl JandaJel^TM resin-bound cyclohexyl ester; In toluene; for 24h; Further stages.; Heating;

DOI:10.1016/j.tetlet.2003.10.168

upstream raw materials:

cyclohexanecarboxylic acid-(2-amino-N-methyl-anilide)

N-methyl-1,2-phenylenediamine

2-nitro-N-methylaniline

cyclohexanecarboxylic acid-(N-methyl-2-nitro-anilide)

Refernces

• 1、 Li, Jianbin,Huang, Chia-Yu,Han, Jing-Tan,Li, Chao-Jun. "Development of a Quinolinium/Cobaloxime Dual Photocatalytic System for Oxidative C-C Cross-Couplings via H2Release". . p. 14148 - 14158. Retrieved 2021/11/27.
• 2、 Zhao, Hong,Li, Zhenlong,Jin, Jian. "Green oxidant H2O2 as a hydrogen atom transfer reagent for visible light-mediated Minisci reaction". supporting information. p. 12533 - 12537. Retrieved 2019/08/21.