3-NONAFLUOROBUTYL-2-IODOPROPANOL

Base Information

• Chemical Name: 3-NONAFLUOROBUTYL-2-IODOPROPANOL
• CAS No.: 80233-96-1
• Molecular Formula: C₇H₆F₉IO
• Molecular Weight: 404.014
• Hs Code.: 2906290090
• Mol file: 80233-96-1.mol

Synonyms:PC5906GB;1-Heptanol,4,4,5,5,6,6,7,7,7-nonafluoro-2-iodo;3-Nonafluorobutyl-2-iodopropanol;

Chemical Property of 3-NONAFLUOROBUTYL-2-IODOPROPANOL

Chemical Property:

• Refractive Index: 1.403
• Boiling Point: 105-110 °C(Press: 16 Torr)
• PKA: 13.93±0.10(Predicted)
• PSA: 20.23000
• Density: 1.972
• LogP: 3.64060

Purity/Quality:

98%Min ^*data from raw suppliers

3-Nonafluorobutyl-2-iodopropanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-NONAFLUOROBUTYL-2-IODOPROPANOL

There total 1 articles about 3-NONAFLUOROBUTYL-2-IODOPROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane (423-39-2) + allyl alcohol (107-18-6) → 3?(perfluoro?n?butyl)?2?iodo?1?propanol (80233-96-1)

Guidance literature:

With mercury(I) iodide; mercury(II) iodide; In N,N-dimethyl-formamide; at 35 ℃; for 1.5h;

Reference yield: 71.0%

3?(perfluoro?n?butyl)?2?iodo?1?propanol (80233-96-1) → 3?(perfluoro?n?butyl)?1,2?epoxypropane (81190-28-5)

Guidance literature:

With sodium hydroxide; In water; at 85 ℃; for 5h; Inert atmosphere;

DOI:10.1071/CH18126

Reference yield:

3?(perfluoro?n?butyl)?2?iodo?1?propanol (80233-96-1) → toluene-4-sulfonic acid 4,4,5,5,6,6,7,7,7-nonafluoroheptyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

2: triethylamine / dichloromethane / 16 h / 4 - 20 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1039/c4tc02557a

upstream raw materials:

1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane

allyl alcohol

Downstream raw materials:

3?(perfluoro?n?butyl)?1,2?epoxypropane

benzyl-bis-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyl)-amine

1-iodine-1H,1H,2H,2H,3H,3H-perfluoroheptane

1-iodo-5,5,6,6,7,7,7-heptafluoroheptane

Refernces

• 1、 Brace, Neal O.. "SOME APPROACHES TO THE SYNTHESIS OF FLUORINATED ALCOHOLS AND ESTERS. II. USE OF F-ALKYL IODIDES FOR THE SYNTHESIS OF F-ALKYL ALKANOLS". . p. 313 - 328. Retrieved 1982.
• 2、 Slodowicz,Barata-Vallejo,Vázquez,Nudelman, N. Sbarbati,Postigo. "Light-induced iodoperfluoroalkylation reactions of carbon-carbon multiple bonds in water". . p. 137 - 143. Retrieved 2012.
• 3、 Beniazza, Redouane,Atkinson, Rachel,Absalon, Christelle,Castet, Frédéric,Denisov, Sergey A.,McClenaghan, Nathan D.,Lastécouères, Dominique,Vincent, Jean-Marc. "Benzophenone vs. Copper/Benzophenone in Light-Promoted Atom Transfer Radical Additions (ATRAs): Highly Effective Iodoperfluoroalkylation of Alkenes/Alkynes and Mechanistic Studies". . p. 2949 - 2961. Retrieved 2016/09/16.