Butanenitrile, 2-hydroxy-3,3-dimethyl-, (R)-

Base Information

• Chemical Name: Butanenitrile, 2-hydroxy-3,3-dimethyl-, (R)-
• CAS No.: 106863-49-4
• Molecular Formula: C6H11NO
• Mol file: 106863-49-4.mol

Synonyms:

Chemical Property of Butanenitrile, 2-hydroxy-3,3-dimethyl-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanenitrile, 2-hydroxy-3,3-dimethyl-, (R)-

There total 15 articles about Butanenitrile, 2-hydroxy-3,3-dimethyl-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

hydrogen cyanide (74-90-8) + pivalaldehyde (630-19-3) → (R)-2-hydroxy-3,3-dimethylbutanenitrile (33350-17-3,84569-91-5,127760-84-3,106863-49-4)

Guidance literature:

In ethyl acetate; for 4.5h; Ambient temperature; (E_.C_. 4.1.2.10), 1000 U/ml, sodium acetate buffer pH 5.4;

DOI:10.1055/s-1990-26945

Reference yield: 89.0%

pivalaldehyde (630-19-3) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → (S)-3,3-dimethyl-2-hydroxybutanenitrile (33350-17-3,84569-91-5,106863-49-4,127760-84-3)

Guidance literature:

With C₄₅H₇₂N₂O₃V; oxygen; In dichloromethane; at 25 ℃; for 2h; optical yield given as %ee; enantioselective reaction;

DOI:10.1039/c0cc00588f

Reference yield: 52.0%

potassium cyanide (151-50-8) + pivalaldehyde (630-19-3) → (R)-2-hydroxy-3,3-dimethylbutanenitrile (33350-17-3,84569-91-5,127760-84-3,106863-49-4)

Guidance literature:

With Prunus mume (R)-hydroxynitrile lyase; citrate buffer; In di-isopropyl ether; for 6h; pH=4.0;

DOI:10.1016/j.tet.2005.08.105

upstream raw materials:

hydrogen cyanide

pivalaldehyde

trimethylsilyl cyanide

2-hydroxy-2-methylpropanenitrile

Downstream raw materials:

(R)-2-hydroxy-3,3-dimethyl-1-aminobutane

Refernces

• 1、 Zheng, Yu-Cong,Ding, Liang-Yi,Jia, Qiao,Lin, Zuming,Hong, Ran,Yu, Hui-Lei,Xu, Jian-He. "A High-Throughput Screening Method for the Directed Evolution of Hydroxynitrile Lyase towards Cyanohydrin Synthesis". . p. 996 - 1000. Retrieved 2021/01/15.
• 2、 Chu, Chang-Ying,Hsu, Chu-Tin,Lo, Po Hsiang,Uang, Biing-Jiun. "Enantioselective silylcyanation of aldehydes catalyzed by new chiral oxovanadium complex". scheme or table. p. 1981 - 1984. Retrieved 2012/03/10.