Technology Process of (S)-Hexahydrodifenidol hydrochloride
There total 3 articles about (S)-Hexahydrodifenidol hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) n-BuLi (1.6M sol. in hexane) / 1.) diethyl ether/hexane, -50 deg C; 2.) diethyl ether/ hexane, 16 h, room temp.
2: 1.) (S)-mandelic acid, CH3CN, 24 h, 20 deg C; 2.) 0.1M NaOH
3: 1.) H2; 2.) HCl (0.5M sol. in ether) / 1.) Pd/C (10percent) / 1.) CH3OH, 2h, room temp.; 2.) ether
With
hydrogenchloride; n-butyllithium; hydrogen;
palladium on activated charcoal;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) n-BuLi (1.6M sol. in hexane) / 1.) diethyl ether/hexane, -50 deg C; 2.) diethyl ether/ hexane, 16 h, room temp.
2: 1.) (S)-mandelic acid, CH3CN, 24 h, 20 deg C; 2.) 0.1M NaOH
3: 1.) H2; 2.) HCl (0.5M sol. in ether) / 1.) Pd/C (10percent) / 1.) CH3OH, 2h, room temp.; 2.) ether
With
hydrogenchloride; n-butyllithium; hydrogen;
palladium on activated charcoal;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) (S)-mandelic acid, CH3CN, 24 h, 20 deg C; 2.) 0.1M NaOH
2: 1.) H2; 2.) HCl (0.5M sol. in ether) / 1.) Pd/C (10percent) / 1.) CH3OH, 2h, room temp.; 2.) ether
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
