N-cyclohexyl-4,4,4-trinitrobutanamide

Base Information

• Chemical Name: N-cyclohexyl-4,4,4-trinitrobutanamide
• CAS No.: 1224594-09-5
• Molecular Formula: C₁₀H₁₆N₄O₇
• Molecular Weight: 304.26
• Mol file: 1224594-09-5.mol

Synonyms:

Chemical Property of N-cyclohexyl-4,4,4-trinitrobutanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclohexyl-4,4,4-trinitrobutanamide

There total 2 articles about N-cyclohexyl-4,4,4-trinitrobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

tetranitromethane (509-14-8) + N-cyclohexyl acrylamide (3066-72-6) → N-cyclohexyl-3-nitroisoxazole-5-carboxamide (1224594-03-9) + N-cyclohexyl-4,4,4-trinitrobutanamide (1224594-09-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 0 - 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jo100319p

Reference yield: 41.0%

tetranitromethane (509-14-8) + N-cyclohexyl acrylamide (3066-72-6) → N-cyclohexyl-4,4,4-trinitrobutanamide (1224594-09-5) + N-cyclohexyl-5-nitroisoxazole-3-carboxamide

Guidance literature:

tetranitromethane; With triethylamine; In 1,4-dioxane; at 0 ℃; for 0.0833333h; Inert atmosphere;

N-cyclohexyl acrylamide; In 1,4-dioxane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/acs.joc.8b03086

upstream raw materials:

tetranitromethane

N-cyclohexyl acrylamide

Refernces

• 1、 Volkova, Yulia A.,Averina, Elena B.,Grishin, Yuri K.,Bruheim, Per,Kuznetsova, Tamara S.,Zefirov, Nikolai S.. "Unexpected heterocyclization of electrophilic alkenes by tetranitromethane in the presence of triethylamine. Synthesis of 3-nitroisoxazoles". supporting information; experimental part. p. 3047 - 3052. Retrieved 2010/07/15.