Technology Process of [4-(4-Amino-benzenesulfonyl)-benzyl]-(2-imino-5-methyl-1,2-dihydro-benzo[cd]indol-6-yl)-methyl-amine
There total 13 articles about [4-(4-Amino-benzenesulfonyl)-benzyl]-(2-imino-5-methyl-1,2-dihydro-benzo[cd]indol-6-yl)-methyl-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NBS / CCl4 / Irradiation
2: DIEA / dimethylformamide
3: DIEA / dimethylformamide
4: Lawesson's reagent / toluene
5: NaOH / ethanol; tetrahydrofuran
6: NH3 / methanol
With
Lawessons reagent; sodium hydroxide; N-Bromosuccinimide; ammonia; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00082a006
- Guidance literature:
-
Multi-step reaction with 11 steps
1: TEA / acetone / 0.5 h / -5 °C
2: NaN3 / acetone; H2O / 0.5 h / -5 °C
3: chlorobenzene / 132 °C
4: BCl3 / nitrobenzene / 28 h / 110 - 115 °C
5: 57.2 percent / 70percent HNO3 / acetic acid / 2 h / 50 °C
6: Raney nickel, hydrazine / tetrahydrofuran / 1.5 h / Heating
7: DIEA / dimethylformamide
8: DIEA / dimethylformamide
9: Lawesson's reagent / toluene
10: NaOH / ethanol; tetrahydrofuran
11: NH3 / methanol
With
Lawessons reagent; sodium hydroxide; sodium azide; TEA; ammonia; nitric acid; boron trichloride; nickel; N-ethyl-N,N-diisopropylamine; hydrazine;
In
tetrahydrofuran; methanol; ethanol; water; acetic acid; nitrobenzene; N,N-dimethyl-formamide; chlorobenzene; acetone; toluene;
DOI:10.1021/jm00082a006