(1S,2R)-1-(2-methylphenyl)-2-nitropropyl ethanethioate

Base Information

• Chemical Name: (1S,2R)-1-(2-methylphenyl)-2-nitropropyl ethanethioate
• CAS No.: 1397266-38-4
• Molecular Formula: C₁₂H₁₅NO₃S
• Molecular Weight: 253.322
• Mol file: 1397266-38-4.mol

Synonyms:

Chemical Property of (1S,2R)-1-(2-methylphenyl)-2-nitropropyl ethanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-1-(2-methylphenyl)-2-nitropropyl ethanethioate

There total 1 articles about (1S,2R)-1-(2-methylphenyl)-2-nitropropyl ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Nitro-1-(2-tolyl)propen (103205-27-2) + tiolacetic acid (507-09-5) → 1-(2-methylphenyl)-2-nitropropyl ethanethioate + (1S,2R)-1-(2-methylphenyl)-2-nitropropyl ethanethioate (1397266-38-4)

Guidance literature:

2-Nitro-1-(2-tolyl)propen; With quinine; In dichloromethane; at 0 ℃; for 0.5h;

tiolacetic acid; In dichloromethane; at 0 ℃; for 6h; Overall yield = 98 %; Overall yield = 53.4 mg; enantioselective reaction;

DOI:10.1039/c2ob26068a DOI:10.1039/c2ob26068a

upstream raw materials:

2-Nitro-1-(2-tolyl)propen

tiolacetic acid

Refernces

• 1、 Yang, Wen,Du, Da-Ming. "Squaramide-catalysed enantio- and diastereoselective sulfa-Michael addition of thioacetic acid to α,β-disubstituted nitroalkenes". . p. 6876 - 6884. Retrieved 2013/01/14.