deoxydihydroqinghaosu

Base Information

• Chemical Name: deoxydihydroqinghaosu
• CAS No.: 72807-92-2
• Molecular Formula: C₁₅H₂₄O₄
• Molecular Weight: 268.353
• Mol file: 72807-92-2.mol

Synonyms:

Chemical Property of deoxydihydroqinghaosu

Chemical Property:

• Melting Point: 140 - 142oC

Purity/Quality:

98% ^*data from raw suppliers

Deoxydihydroartemisinin(α,βMixture) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Deoxydihydroartemisinin is used in biological studies antimalarial and possible antitumor effects via oxidative stress, modulated by hypoxia, in microendothelial cells.

Technology Process of deoxydihydroqinghaosu

There total 11 articles about deoxydihydroqinghaosu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide (255730-18-8) → β-2-deoxy-9-epidihydroartemisinin (1356857-18-5) + (2S, 3R, 6S)-2-(3-oxobutyl)-3-methyl-6-<(R)2-propanal>-cyclohexanone (107466-88-6) + deoxydihydroqinghaosu (72807-92-2)

Guidance literature:

With 1-Benzyl-1,4-dihydronicotinamide; lumiflavin; In acetonitrile; at 20 ℃; for 6h; pH=7.4; aq. phosphate buffer; Inert atmosphere;

DOI:10.1002/cmdc.201000225

Reference yield:

C15H24O5 (958447-25-1,149588-86-3) → β-2-deoxy-9-epidihydroartemisinin (1356857-18-5) + (2S, 3R, 6S)-2-(3-oxobutyl)-3-methyl-6-<(R)2-propanal>-cyclohexanone (107466-88-6) + deoxydihydroqinghaosu (72807-92-2)

Guidance literature:

With 1-Benzyl-1,4-dihydronicotinamide; lumiflavin; In acetonitrile; at 20 ℃; for 1.33333h; pH=7.4; aq. phosphate buffer; Inert atmosphere;

DOI:10.1002/cmdc.201000225

Reference yield:

dihydroartemisinin (71939-50-9) → β-2-deoxy-9-epidihydroartemisinin (1356857-18-5) + (2S, 3R, 6S)-2-(3-oxobutyl)-3-methyl-6-<(R)2-propanal>-cyclohexanone (107466-88-6) + deoxydihydroqinghaosu (72807-92-2)

Guidance literature:

With 1-Benzyl-1,4-dihydronicotinamide; lumiflavin; In acetonitrile; at 20 ℃; for 1.33333h; pH=7.4; aq. phosphate buffer; Inert atmosphere;

DOI:10.1002/cmdc.201000225

upstream raw materials:

dihydroartemisinin

p-[(10-dihydroartemisininoxy)methyl]benzoic acid

4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide

C₁₅H₂₄O₅

Refernces

• 1、 Haynes, Richard K.,Chan, Wing-Chi,Wong, Ho-Ning,Li, Ka-Yan,Wu, Wai-Keung,Fan, Kit-Man,Sung, Herman H. Y.,Williams, Ian D.,Prosperi, Davide,Melato, Sergio,Coghi, Paolo,Monti, Diego. "Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: Relationship with flavoenzyme function and antimalarial mechanism of action". experimental part. p. 1282 - 1299. Retrieved 2011/01/04.