2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde

Base Information

• Chemical Name: 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde
• CAS No.: 133909-85-0
• Molecular Formula: C₂₃H₂₁ClFN₅O
• Molecular Weight: 437.904
• Mol file: 133909-85-0.mol

Synonyms:

Chemical Property of 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde

There total 3 articles about 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-n-butyl-4-chloro-5-hydroxymethylimidazole (79047-41-9) → 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde (133909-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / 1.0 N aq. ceric ammonium nitrate / acetic acid / 3 h / 25 °C

2: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

With ammonium cerium(IV) nitrate; sodium methylate; In acetic acid;

DOI:10.1021/jm00112a031

Reference yield:

5-fluoro-4-(4'-methylbiphenyl-2-yl)-1,2,3-triazole (133910-07-3) → 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde (133909-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

2: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

With N-Bromosuccinimide; sodium methylate; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1021/jm00112a031

Reference yield:

2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde (83857-96-9) + 4-(4'-Bromomethyl-biphenyl-2-yl)-5-fluoro-1H-[1,2,3]triazole → 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde (133909-85-0)

Guidance literature:

With sodium methylate; Multistep reaction; 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h;

DOI:10.1021/jm00112a031

upstream raw materials:

2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

2-n-butyl-4-chloro-5-hydroxymethylimidazole

5-fluoro-4-(4'-methylbiphenyl-2-yl)-1,2,3-triazole

Refernces