Technology Process of 2-(3-(4-methoxybenzyloxy)propyl)-5-bromo-3-((E)-dec-1-enyl)-4,6-dimethylpyridine
There total 9 articles about 2-(3-(4-methoxybenzyloxy)propyl)-5-bromo-3-((E)-dec-1-enyl)-4,6-dimethylpyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
4: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
With
piperidine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butylnitrite; hydrogen; bromine; palladium diacetate; sodium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; ethanol; Bromoform; water; toluene;
1: Sandmeyer type reaction / 2: Sonogashira coupling / 4: Suzuki coupling;
DOI:10.1021/jo2013669
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: bromine; acetic acid / 1.25 h / 20 °C / Inert atmosphere
1.2: Inert atmosphere; Cooling with ice
2.1: tert.-butylnitrite; bromine / Bromoform / 2 h / 20 °C
3.1: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
4.1: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 1 h
5.1: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
With
piperidine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butylnitrite; hydrogen; bromine; palladium diacetate; sodium carbonate; acetic acid; triethylamine; triphenylphosphine;
In
tetrahydrofuran; ethanol; Bromoform; water; toluene;
2.1: Sandmeyer type reaction / 3.1: Sonogashira coupling / 5.1: Suzuki coupling;
DOI:10.1021/jo2013669
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dibromoborane dimethylsulfide / dichloromethane / 4 h / 0 - 20 °C
1.2: 0.25 h / 0 °C
2.1: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 5 h / Inert atmosphere; Reflux
With
dibromoborane dimethylsulfide; palladium diacetate; sodium carbonate; triphenylphosphine;
In
ethanol; dichloromethane; water; toluene;
2.1: Suzuki coupling;
DOI:10.1021/jo2013669