Technology Process of 1-(2,6-bismethyl-phenyl)-6-methoxy-4-methyl-2,3,5,9,9b-pentaazacyclopenta[a]naphthalene
There total 6 articles about 1-(2,6-bismethyl-phenyl)-6-methoxy-4-methyl-2,3,5,9,9b-pentaazacyclopenta[a]naphthalene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid; nitric acid / 2 h / 0 - 20 °C
1.2: pH 9
2.1: 16 h / 60 °C
2.2: pH 6
3.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 750.08 Torr
4.1: ethanol / 3 h / 20 °C
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide
6.1: hydrazine hydrate / ethanol; dichloromethane / 20 °C
7.1: dichloromethane / 48 h / 40 °C
7.2: 20 °C
With
sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ethanol / 3 h / 20 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide
3.1: hydrazine hydrate / ethanol; dichloromethane / 20 °C
4.1: dichloromethane / 48 h / 40 °C
4.2: 20 °C
With
hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 16 h / 60 °C
1.2: pH 6
2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 750.08 Torr
3.1: ethanol / 3 h / 20 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide
5.1: hydrazine hydrate / ethanol; dichloromethane / 20 °C
6.1: dichloromethane / 48 h / 40 °C
6.2: 20 °C
With
palladium 10% on activated carbon; hydrogen; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;